A

Andreola, Fausto and Calvisi, Diego Francesco and Elizondo, Guillermo and Jakowlew, Sonia B. and Mariano, Jennifer and Gonzalez, Frank J. and De Luca, Luigi M. (2004) Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion. Hepatology, Vol. 39 (1), p. 157-166. eISSN 1527-3350. Article.

B

Balzani, Stella (2012) L'Attivazione del complesso MYBL2-LIN9 contribuisce all'epatocancerogenesi umana ed identifica un sottogruppo di epatocarcinomi con p53 mutato. Doctoral Thesis.

C

Calvisi, Diego Francesco and Conner, Elizabeth A. and Ladu, Sara and Lemmer, Eric R. and Factor, Valentina M. and Thorgeirsson, Snorri S. (2005) Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. Journal of Hepatology, Vol. 42 (6), p. 842-849. ISSN 0168-8278. Article.

Calvisi, Diego Francesco and Factor, Valentina M. and Ladu, Sara and Conner, Elizabeth A. and Thorgeirsson, Snorri S. (2004) Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice. Gastroenterology, Vol. 126 (5), p. 1374-1386. ISSN 0016-5085. Article.

Calvisi, Diego Francesco and Frau, Maddalena and Tomasi, Maria Lauda and Feo, Francesco and Pascale, Rosa Maria (2012) Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison. Biochimica et Biophysica Acta (BBA): reviews on cancer, Vol. 1826 (1), p. 215-237. eISSN 1879-2561. Article.

Calvisi, Diego Francesco and Ladu, Sara and Conner, Elizabeth A. and Factor, Valentina M. and Thorgeirsson, Snorri S. (2004) Disregulation of E-cadherin in transgenic mouse models of liver cancer. Laboratory Investigation, Vol. 84 , p. 1137-1147. eISSN 1530-0307. Article.

Calvisi, Diego Francesco and Ladu, Sara and Conner, Elizabeth A. and Seo, Daekwan and Hsieh, Jer Tsong and Factor, Valentina M. and Thorgeirsson , Snorri S. (2011) Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. Journal of Hepatology, Vol. 54 (2), p. 311-319. ISSN 0168-8278. Article.

Calvisi, Diego Francesco and Ladu, Sara and Gorden, Alexis and Conner, Elizabeth A. and Lee, Ju-Seog and Factor, Valentina M. and Thorgeirsson, Snorri S. (2006) Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology, Vol. 130 (4), p. 1117-1128. ISSN 0016-5085. Article.

Calvisi, Diego Francesco and Ladu, Sara and Gorden, Alexis and Farina, Miriam and Lee, Ju-Seog and Conner, Elizabeth A. and Schroeder, Insa S. and Factor, Valentina M. and Thorgeirsson, Snorri S. (2007) Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. The Journal of Clinical Investigation, Vol. 117 (9), p. 2713-2722. eISSN 1558-8238. Article.

Calvisi, Diego Francesco and Ladu, Sara and Hironaka, Koji and Factor, Valentina M. and Thorgeirsson, Snorri S. (2004) Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer. Journal of Hepatology, Vol. 41 (5), p. 815-822. ISSN 0168-8278. Article.

Calvisi, Diego Francesco and Pinna, Federico and Ladu, Sara and Muroni, Maria Rosaria and Frau, Maddalena and Demartis, Ilaria and Tomasi, Maria Lauda and Sini, Marcella and Simile, Maria Maddalena and Seddaiu, Maria Antonietta and Feo, Francesco and Pascale, Rosa Maria (2010) The Degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. International Journal of Cancer, Vol. 126 (5), p. 1275-1281. eISSN 1097-0215. Article.

Calvisi, Diego Francesco and Pinna, Federico and Ladu, Sara and Pellegrino, Rossella and Muroni, Maria Rosaria and Simile, Maria Maddalena and Frau, Maddalena and Tomasi, Maria Lauda and De Miglio, Maria Rosaria and Seddaiu, Maria Antonietta and Daino, Lucia and Sanna, Valeria and Feo, Francesco and Pascale, Rosa Maria (2008) Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease. Carcinogenesis, Vol. 29 (8), p. 1639-1647. ISSN 1460-2180. Article.

Calvisi, Diego Francesco and Pinna, Federico and Ladu, Sara and Pellegrino, Rossella and Simile, Maria Maddalena and Frau, Maddalena and De Miglio, Maria Rosaria and Tomasi, Maria Lauda and Sanna, Valeria and Muroni, Maria Rosaria and Feo, Francesco and Pascale, Rosa Maria (2009) Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. Gut, Vol. 58 (5), p. 679-687. eISSN 1468-3288 . Article.

Calvisi, Diego Francesco and Pinna, Federico and Meloni, Floriana and Ladu, Sara and Pellegrino, Rossella and Sini, Marcella and Daino, Lucia and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Virdis, Patrizia and Frau, Maddalena and Tomasi, Maria Lauda and Seddaiu, Maria Antonietta and Muroni, Maria Rosaria and Feo, Francesco and Pascale, Rosa Maria (2008) Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma. Cancer Research, Vol. 68 (11), p. 4192-4200. eISSN 0008-5472. Article.

Calvisi, Diego Francesco and Pinna, Federico and Pellegrino, Rossella and Sanna, Vanna Annunziata and Sini, Marcella and Daino, Lucia and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Frau, Maddalena and Tomasi, Maria Lauda and Seddaiu, Maria Antonietta and Muroni, Maria Rosaria and Feo, Francesco and Pascale, Rosa Maria (2008) Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control. International Journal of Cancer, Vol. 123 (9), p. 2057-2064. eISSN 1097-0215. Article.

Calvisi, Diego Francesco and Simile, Maria Maddalena and Ladu, Sara and Frau, Maddalena and Evert, Matthias and Tomasi, Maria Lauda and Demartis, Maria I. and Daino, Lucia Maria Elisa and Seddaiu, Maria Antonietta and Brozzetti, Stefania and Feo, Francesco and Pascale, Rosa Maria (2011) Activation of MYBL2-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of human hepatocellular carcinoma with mutant p53. Hepatology, Vol. 53 (4), p. 1226-1236. eISSN 1527-3350. Article.

Calvisi, Diego Francesco and Simile, Maria Maddalena and Ladu, Sara and Frau, Maddalena and Evert, Matthias and Tomasi, Maria Lauda and Demartis, Maria I. and Daino, Lucia Maria Elisa and Seddaiu, Maria Antonietta and Brozzetti, Stefania and Feo, Francesco and Pascale, Rosa Maria (2011) Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. Hepatology, Vol. 53 (4), p. 1226-1236. ISSN 0270-9139. eISSN 1527-3350. Article.

Calvisi, Diego Francesco and Simile, Maria Maddalena and Ladu, Sara and Pellegrino, Rossella and De Murtas, Valentina and Pinna, Federico and Tomasi, Maria Lauda and Frau, Maddalena and Virdis, Patrizia and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Pascale, Rosa Maria and Feo, Francesco (2007) Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis. International Journal of Cancer, Vol. 121 (11), p. 2410-2420. eISSN 1097-0215. Article.

Calvisi, Diego Francesco and Simile, Maria Maddalena and Ladu, Sara and Pellegrino, Rossella and De Murtas, Valentina and Tomasi, Maria Lauda and Virdis, Patrizia and De Miglio, Maria Rosaria and Pascale, Rosa Maria and Feo, Francesco (2007) Role of perturbation of methionine metabolism and global dna methylation in the generation of genomic instability in transgenic mouse models of liver cancer. Journal of Hepatology, Vol. 46 (Supplement 1), S137. ISSN 0168-8278. Article.

Capobianco, Giampiero and Pili, Francesca and Contini, Marcella and De Miglio, Maria Rosaria and Marras, Vincenzo and Santeufemia, Davide Adriano and Cherchi, Claudio and Dessole, Margherita and Cherchi, Pier Luigi and Cossu Rocca, Paolo Alessandro (2012) Analysis of epidermal growth factor receptor (EGFR) status in endometrial stromal sarcoma. European Journal of Gynaecological Oncology, Vol. 33 (6), p. 629-632. ISSN 0392-2936. Article.

D

De Franceschi, Lucia and Biondani, Andrea and Carta, Franco and Turrini, Francesco Michelangelo and Laudanna, Carlo and Deana, Renzo and Brunati, Anna Maria and Turretta, Loris and Iolascon, Achille and Perrotta, Silverio and Elson, Ari and Bulato, Cristina and Brugnara, Carlo (2008) PTPε has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics, Vol. 8 (22), p. 4695-4708. eISSN 1615-9861. Article.

De Miglio, Maria Rosaria and Canzian, Federico and Pascale, Rosa Maria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Romeo, Giovanni and Feo, Francesco (1999) Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10. Cancer Research, Vol. 59 (18), p. 4651-4657. eISSN 0008-5472. Article.

De Miglio, Maria Rosaria and Mura, Antonica and Uras, Maria Gabriela and Manca, Alessandra and Contini, Marcella and Murgia, Luciano and Zinellu, Angelo and Sotgia, Salvatore and Carru, Ciriaco and Massarelli, Giovannino and Cossu Rocca, Paolo Alessandro (2010) High sensitivity of reverse-hybridization methodology in the detection of KRAS mutations from formalin-fixed paraffin-embedded colorectal cancer samples. Diagnostic Molecular Pathology, Vol. 19 (4), p. 201-208. ISSN 1052-9551. Article.

De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Simile, Maria Maddalena and Calvisi, Diego Francesco and Tolu, Paola and Deiana, Luca and Carru, Angelo and Bonelli, Gabriella and Feo, Francesco and Pascale, Rosa Maria (2000) Implication of Bcl-2 family genes in basal and d-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions. Hepatology, Vol. 31 (4), p. 956-965. eISSN 1527-3350. Article.

De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Simile, Maria Maddalena and Virdis, Patrizia and Asara, Giuseppina and Frau, Maddalena and Calvisi, Diego Francesco and Seddaiu, Maria Antonietta and Pascale, Rosa Maria and Feo, Francesco (2001) Frequent loss of heterozygosity at the Hcr1 (hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain. Hepatology, Vol. 33 (5), p. 1110-1117. eISSN 1527-3350. Article.

De Miglio, Maria Rosaria and Pascale, Rosa Maria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Virdis, Patrizia and Bosinco, Giovanni M. and Frau, Maddalena and Seddaiu, Maria Antonietta and Ladu, Sara and Feo, Francesco (2002) Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis. Cancer Research, Vol. 62 (15), p. 4459-4463. eISSN 0008-5472. Article.

De Miglio, Maria Rosaria and Pascale, Rosa Maria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Virdis, Patrizia and Kwong, Kelvin M.-T. and Wong, Leslie K.L. and Bosinco, Giovanni M. and Pulina, Franca Rossana and Calvisi, Diego Francesco and Frau, Maddalena and Wood, Geoffrey A. and Archer, Michael C. and Feo, Francesco (2004) Polygenic control of hepatocarcinogenesis in Copenhagen × F344 rats. International Journal of Cancer, Vol. 111 (1), p. 9-16. eISSN 1097-0215. Article.

De Miglio, Maria Rosaria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Virdis, Patrizia and Asara, Giuseppina and Frau, Maddalena and Bosinco, Giovanni M. and Seddaiu, Maria Antonietta and Daino, Lucia and Feo, Francesco and Pascale, Rosa Maria (2003) Phenotypic reversion of rat neoplastic liver nodules is under genetic control. International Journal of Cancer, Vol. 105 (1), p. 70-75. eISSN 1097-0215. Article.

De Miglio, Maria Rosaria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Pusceddu, Stefano and Calvisi, Diego Francesco and Carru, Angelo and Seddaiu, Maria Antonietta and Daino, Lucia and Deiana, Luca and Pascale, Rosa Maria and Feo, Francesco (1999) Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain. Molecular Carcinogenesis, Vol. 25 (1), p. 21-29. ISSN 0899-1987. Article.

De Miglio, Maria Rosaria and Virdis, Patrizia and Calvisi, Diego Francesco and Frau, Maddalena and Muroni, Maria Rosaria and Simile, Maria Maddalena and Daino, Lucia and Careddu, Giovanni Mario and Sanna Passino, Eraldo and Pascale, Rosa Maria and Feo, Francesco (2006) Mapping a sex hormone–sensitive gene determining female resistance to liver carcinogenesis in a congenic f344.bn-hcs4 rat. Cancer Research, Vol. 66 (21), p. 10384-10390. eISSN 0008-5472. Article.

De Miglio, Maria Rosaria and Virdis, Patrizia and Calvisi, Diego Francesco and Frau, Maddalena and Muroni, Maria Rosaria and Simile, Maria Maddalena and Daino, Lucia and Careddu, Giovanni Mario and Sanna Passino, Eraldo and Pascale, Rosa Maria and Feo, Francesco (2007) Mapping a sex-hormone sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.bn-hcs4 rat. Journal of Hepatology, Vol. 46 (Supplement 1), s34. ISSN 0168-8278. Article.

De Miglio, Maria Rosaria and Virdis, Patrizia and Calvisi, Diego Francesco and Mele, Daniela and Muroni, Maria Rosaria and Frau, Maddalena and Pinna, Federico and Tomasi, Maria Lauda and Simile, Maria Maddalena and Pascale, Rosa Maria and Feo, Francesco (2007) Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/ß-catenin pathway and progression of early lesions in the rat. Carcinogenesis, Vol. 28 (11), p. 2367-2374. ISSN 1460-2180. Article.

Demartis , Maria Ilaria (2011) Controllo genetico dei regolatori del ciclo cellulare attraverso il complesso SKP2/CKS1 ubiquitina ligasi nel cancro epatico dei roditori e sua associazione con la prognosi dell'epatocarcinoma umano. Doctoral Thesis.

Dettori, Manuela (2011) Attività antitumorale del sorafenib nei pazienti con epatocarcinoma. Doctoral Thesis.

E

Evert, Matthias and Frau, Maddalena and Tomasi, Maria Lauda and Latte, Gavinella and Simile, Maria Maddalena and Seddaiu, Maria Antonietta and Zimmermann, A. and Ladu, Sara and Staniscia, T. and Brozzetti, Stefania and Solinas, Maria Giuliana and Dombrowski, F. and Feo, Francesco and Pascale, Rosa Maria and Calvisi, Diego Francesco (2013) Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value. British Journal of Cancer, Vol. 109 , p. 2654-2664. ISSN 0007-0920. eISSN 1532-1827. Article.

F

Falvella, F. Stefania and Pascale, Rosa Maria and Gariboldi , Manuela and Manenti, Giacomo and De Miglio, Maria Rosaria and Simile, Maria Maddalena and Dragani, Tommaso A. and Feo, Francesco (2002) Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis, Vol. 23 (11), p. 1933-1936. ISSN 1460-2180. Article.

Feo, Francesco and De Miglio, Maria Rosaria and Simile, Maria Maddalena and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Frau, Maddalena and Pascale, Rosa Maria (2006) Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition. Biochimica et Biophysica Acta. Reviews on Cancer, Vol. 1765 (2), p. 126-147. ISSN 0304-419X. Article.

Feo, Francesco and Frau, Maddalena and Pascale, Rosa Maria (2008) Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis: Editorial. World Journal of Gastroenterology, Vol. 14 (43), p. 6601-6615. ISSN 1007-9327. Article.

Feo, Francesco and Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Calvisi, Diego Francesco (2000) Genetic alterations in liver carcinogenesis: implication for new preventive therapeutic strategies. Critical Reviews in Oncogenesis, Vol. 11 (1), p. 19-62. ISSN 0893-9675. Article.

Feo, Francesco and Poli, Giuseppe (2010) Special issue on “molecular mechanisms and new therapeutic targets in human carcinogenesis”. Molecular Aspects of Medicine, Vol. 31 (2), p. 133-134. eISSN 1872-9452. Article.

Frau, Maddalena and Biasi, Fiorella and Feo, Francesco and Pascale, Rosa Maria (2010) Prognostic markers and putative therapeutic targets for hepatocellular carcinoma. Molecular Aspects of Medicine, Vol. 31 (2), p. 179-193. eISSN 1872-9452. Article.

Frau, Maddalena and Feo, Francesco and Pascale, Rosa Maria (2013) Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. Journal of Hepatology, Vol. 59 (4), p. 830-841. ISSN 0168-8278. Article.

Frau, Maddalena and Ladu, Sara and Calvisi, Diego Francesco and Simile, Maria Maddalena and Bonelli, Piero and Daino, Lucia and Tomasi, Maria Lauda and Seddaiu, Maria Antonietta and Feo, Francesco and Pascale, Rosa Maria (2011) Mybl2expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype. Journal of Hepatology, Vol. 55 (1), p. 111-119. eISSN 1600-0641. Article.

Frau, Maddalena and Simile, Maria Maddalena and Tomasi, Maria Lauda and Demartis , Maria Ilaria and Daino, Lucia Maria Elisa and Seddaiu, Maria Antonietta and Brozzetti, Stefania and Feo, Claudio F. and Massarelli, Giovannino and Solinas, Maria Giuliana and Feo, Francesco and Lee, Ju-Seog and Pascale, Rosa Maria (2012) An Expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis. Cellular Oncology, Vol. 35 (3), p. 163-173. eISSN 2211-3436. Article.

Frau, Maddalena and Tomasi, Maria Lauda and Simile, Maria Maddalena and Demartis, Maria Ilaria and Salis, Fabiana and Latte, Gavinella and Calvisi, Diego Francesco and Seddaiu, Maria Antonietta and Daino, Lucia Maria Elisa and Feo, Claudio F. and Brozzetti, Stefania and Solinas, Maria Giuliana and Yamashita, Satoshi and Ushijima, Toshikazu and Feo, Francesco and Pascale, Rosa Maria (2012) Role of transcriptional and post-transcriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology, Vol. 56 (1), p. 165-175. eISSN 1527-3350. Article.

Frau, Maddalena and Tomasi, Maria Lauda and Simile, Maria Maddalena and Demartis , Maria Ilaria and Salis, Fabiana and Latte, Gavinella and Calvisi, Diego Francesco and Seddaiu, Maria Antonietta and Daino, Lucia and Feo, Claudio F. and Brozzetti, Stefania and Solinas, Maria Giuliana and Yamashita, Satoshi and Ushijima, Toshikazu and Feo, Francesco and Pascale, Rosa Maria (2012) Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Hepatology, Vol. 56 (1), p. 165-175. ISSN 0270-9139. eISSN 1527-3350. Article.

G

Gariboldi, Manuela and Pascale, Rosa Maria and Manenti, Giacomo and De Miglio, Maria Rosaria and Calvisi, Diego Francesco and Carru, Angelo and Dragani, Tommaso A. and Feo, Francesco (1999) Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosomine in the resistant BFF1 rat strain. Carcinogenesis, Vol. 20 (7), p. 1363-1368. ISSN 1460-2180. Article.

H

Hironaka, Koji and Factor, Valentina M. and Calvisi, Diego Francesco and Conner, Elizabeth A. and Thorgeirsson, Snorri S. (2003) Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis. Laboratory Investigation, Vol. 83 (5), p. 643-654. eISSN 1530-0307. Article.

L

Ladu, Sara and Calvisi, Diego Francesco and Conner, Elizabeth A. and Farina, Miriam and Factor, Valentina M. and Thorgeirsson, Snorri S. (2008) E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. Gastroenterology, Vol. 135 (4), p. 1322-1332. ISSN 0016-5085. Article.

Latte, Gavinella (2013) Ruolo della regolazione trascrizionale e post- trascrizionale della metionina adenosiltrasferasi nel corso dell'epatocancerogenesi. Doctoral Thesis.

Lee, Ju-Seog and Chu, In-Sun and Heo, Jeonghoon and Calvisi, Diego Francesco and Sun, Zongtang and Roskams, Tania and Durnez, Anne and Demetris, Anthony J. and Thorgeirsson, Snorri S. (2004) Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology, Vol. 40 (3), p. 667-676. eISSN 1527-3350. Article.

Lee, Ju-Seog and Chu, In-Sun and Mikaelyan, Arsen and Calvisi, Diego Francesco and Heo, Jeonghoon and Reddy, Janardan K. and Thorgeirsson, Snorri S. (2004) Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nature Genetics, Vol. 36 (12), p. 1306-1311. eISSN 1546-1718. Article.

Lee, Ju-Seog and Heo, Jeonghoon and Libbrecht, Louis and Chu, In-Sun and Kaposi-Novak, Pal and Calvisi, Diego Francesco and Mikaelyan, Arsen and Roberts, Lewis R. and Demetris, Anthony J. and Sun, Zongtang and Nevens, Frederik and Roskams, Tania and Thorgeirsson, Snorri S. (2006) A Novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nature Medicine, Vol. 12 (4), p. 410-416. eISSN 1546-170X. Article.

Lutasa, Maria U. and Salis, Fabiana and Urtasun, Raquel and Garcia-Irigoyen, Oihane and Elizalde, María and Uriarte, Iker and Santamaria, Monica and Feo, Francesco and Pascale, Rosa Maria and Prieto, Jesús and Berasain, Carmen and Avila, Matías A. (2012) Regulation of Amphiregulin gene expression by ß-catenin signaling in human Hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS One, Vol. 7 (12), e52711. eISSN 1932-6203. Article.

M

Manenti, Giacomo and Galvan, Antonella and Falvella, F. Stefania and Pascale, Rosa Maria and Spada, Elena and Milani, Silvano and González Neira, Anna and Feo, Francesco and Dragani, Tommaso A. (2008) Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus. Hepatology, Vol. 48 (2), p. 617-623. eISSN 1527-3350. Article.

Martínez-Chantar, M. Luz and Vázquez-Chantada, Mercedes and Ariz, Usue and Martínez, Nuria and Varela, Marta and Luka, Zigmund and Capdevila, Antonieta and Rodríguez, Juan and Aransay, Ana María and Matthiesen, Rune and Yang, Heping and Calvisi, Diego Francesco and Esteller, Manel and Fraga, Mario and Lu, Shelly C. and Wagner, Conrad and Mato, José M. (2008) Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology, Vol. 47 (4), p. 1191-1199. eISSN 1527-3350. Article.

Mura, Silvia (2010) Ruolo del Lapatinib nel trattamento adiuvante del carcinoma mammario HER-2 positivo. Doctoral Thesis.

P

Pascale, Rosa Maria and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Simile, Maria Maddalena and Daino, Lucia and Seddaiu, Maria Antonietta and Nufris, Alessandra and Gaspa, Leonardo and Deiana, Luca and Feo, Francesco (1996) c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model. International Journal of Cancer, Vol. 68 (1), p. 136-142. eISSN 1097-0215. Article.

Pascale, Rosa Maria and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Simile, Maria Maddalena and Daino, Lucia and Seddaiu, Maria Antonietta and Pusceddu, Stefano and Gaspa, Leonardo and Calvisi, Diego Francesco and Manenti, Giacomo and Feo, Francesco (1998) Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat. Hepatology, Vol. 27 (2), p. 452-461. eISSN 1527-3350. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and Calvisi, Diego Francesco and Frau, Maddalena and Muroni, Maria Rosaria and Seddaiu, Maria Antonietta and Daino, Lucia and Muntoni, Maria Donatella and De Miglio, Maria Rosaria and Thorgeirsson, Snorri S. and Feo, Francesco (2005) Role of HSP90, CDC37, and CRM1 as modulators of P16INK4A activity in rat liver carcinogenesis and human liver cancer. Hepatology, Vol. 42 (6), p. 1310-1319. eISSN 1527-3350. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Feo, Francesco (2002) Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine. Alcohol, Vol. 27 (3), p. 193-198. ISSN 0741-8329. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Asara, Giuseppina and Casabona, Daniela and Frau, Maddalena and Seddaiu, Maria Antonietta and Feo, Francesco (2002) Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Hepatology, Vol. 35 (6), p. 1341-1350. eISSN 1527-3350. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Gaspa, Leonardo and Dragani, Tommaso A. and Feo, Francesco (1996) The BN rat strain carries dominant hepatocarcinogen resistance loci. Carcinogenesis, Vol. 17 (8), p. 1765-1768. ISSN 1460-2180. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Nufris, Alessandra and Seddaiu, Maria Antonietta and Muroni, Maria Rosaria and Danni, Oliviero and Rao , Kalipatnapu N. and Feo, Francesco (1995) Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydrocpiandrosterone in preneoplastic liver nodules. Carcinogenesis, Vol. 16 (7), p. 1537-1542. ISSN 1460-2180. Article.

Pascale, Rosa Maria and Simile, Maria Maddalena and De Miglio, Maria Rosaria and Nufris , Alessandra and Daino, Lucia and Seddaiu, Maria Antonietta and Rao, Prema M. and Rajalakshmi, Srinivasan and Sarma, Dittakavi S. R. and Feo, Francesco (1995) Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis, Vol. 16 (2), p. 427-430. ISSN 1460-2180. Article.

Piana, Andrea Fausto and Sotgiu, Giovanni and Muroni, Maria Rosaria and Cossu Rocca, Paolo Alessandro and Castiglia, Paolo Giuseppino and De Miglio, Maria Rosaria (2014) HPV infection and triple-negative breast cancers: an Italian case-control study. Virology Journal, Vol. 11 (190). ISSN 1743-422X. Article.

Pilo, Maria Giulia (2014) La Completa inibizione della via di segnale mTORC1 è necessaria per la soppressione dell’epatocancerogenesi indotta dall’iperespressione dei protooncogeni AKT e N-Ras nel topo. Doctoral Thesis. Item availablity restricted.

Pinna, Federico (2009) Controllo della progressione del carcinoma epatocellulare umano da parte della degradazione dell'oncosoppressore DUSP1. Doctoral Thesis.

Pittalis, Maria (2012) Valutazione di efficacia di un antiangiogenetico (Bevacizumab) associato a chemioterapia in pazienti con carcinoma della mammella metastatico. Doctoral Thesis.

Porcu, Chiara (2010) Gli Inibitori tirosin-kinasici nel trattamento del carcinoma renale. Doctoral Thesis.

Putzu, Carlo (2009) Razionale all'uso degli inibitori del recettore tirosin-chinasico HER1/EGFR nel trattamento del NSCLC. Doctoral Thesis.

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Salis, Fabiana (2013) Regulation of amphiregulin gene expression by ß-catenin in human hepatocarcinoma cells: a novel crosstalk between FGF19 and the EGFR system. Doctoral Thesis.

Sanna, Valeria (2009) Studio della regolazione genetica della via di trasduzione del segnale iNOS dipendente nell'epatocarcinoma sperimentale e umano. Doctoral Thesis.

Simile, Maria Maddalena and Banni, Sebastiano and Angioni, Elisabetta and Carta, Gianfranca and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Calvisi, Diego Francesco and Carru, Angelo and Pascale, Rosa Maria and Feo, Francesco (2001) 5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication. Journal of Hepatology, Vol. 34 (3), p. 386-394. ISSN 0168-8278. Article.

Simile, Maria Maddalena and De Miglio, Maria Rosaria and Calvisi, Diego Francesco and Muroni, Maria Rosaria and Frau, Maddalena and Asara, Giuseppina and Daino, Lucia and Deiana, Luca and Pascale, Rosa Maria and Feo, Francesco (2001) Long-term dehydroepiandrosterone and 16-fluoro-5-androsten-17-one administration enhances DNA synthesis and induces expression of c-fos and c-Ha-ras in a selected population of preneoplastic lesions in liver of diethylnitrosamine-initiated rats. Carcinogenesis, Vol. 22 (2), p. 301-308. ISSN 1460-2180. Article.

Simile, Maria Maddalena and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Frau, Maddalena and Asara, Giuseppina and Serra, Silvia and Muntoni, Maria Donatella and Seddaiu, Maria Antonietta and Daino, Lucia and Feo, Francesco and Pascale, Rosa Maria (2004) Downregulation of c-myc and cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. Carcinogenesis, Vol. 25 (3), p. 333-341. ISSN 1460-2180. Article.

Simile, Maria Maddalena and Pagnan, Gabriella and Pastorino, Fabio and Brignole, Chiara and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Asara, Giuseppina and Frau, Maddalena and Seddaiu, Maria Antonietta and Calvisi, Diego Francesco and Feo, Francesco and Ponzoni, Mirco and Pascale, Rosa Maria (2005) Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-kB and Mat1A genes in early stages of rat liver carcinogenesis. Carcinogenesis, Vol. 26 (2), p. 417-427. ISSN 1460-2180. Article.

Simile, Maria Maddalena and Pascale, Rosa Maria and De Miglio, Maria Rosaria and Daino, Lucia and Seddaiu, Maria Antonietta and Gaspa, Leonardo and Feo, Francesco (1994) Correlation between S-adenosyl-l-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. Cancer Letters, Vol. 79 (1), p. 9-16. eISSN 1872-7980. Article.

Simile, Maria Maddalena and Pascale, Rosa Maria and De Miglio, Maria Rosaria and Nufris , Alessandra and Daino, Lucia and Seddaiu, Maria Antonietta and Muroni, Maria Rosaria and Rao, Kalipatnapu N. (1995) Inhibition by dehydroepiandrosterone of growth and progression of persistent liver nodules in experimental rat liver carcinogenesis. International Journal of Cancer, Vol. 62 (2), p. 210-215. eISSN 1097-0215. Article.

Simile, Maria Maddalena and Saviozzi, Michela and De Miglio, Maria Rosaria and Muroni, Maria Rosaria and Nufris, Alessandra and Pascale, Rosa Maria and Malvaldi, Gino and Feo, Francesco (1996) Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver puptative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats. Carcinogenesis, Vol. 17 (7), p. 1533-1537. ISSN 1460-2180. Article.

Sini, Marcella (2009) Segnali di proliferazione e apoptosi sono sotto controllo genetico durante la cancerogenesi epatica di ratto. Doctoral Thesis.

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Tilocca, Pier Luigi (2013) Ruolo del gene YAP e della via YAP/CTGF nel corso della cancerogenesi epatica nel ratto e nell'uomo. Doctoral Thesis.

Tomasi, Maria Lauda and Iglesias-Ara, Ainhoa and Yang, Heping and Ramani, Komal and Feo, Francesco and Pascale, Rosa Maria and Martínez-Chantar, M. Luz and Mato, José M. and Lu, Shelly C. (2009) S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis. Gastroenterology, Vol. 136 (3), p. 1025-1036. ISSN 0016-5085. Article.

Tomasi, Maria Lauda and Ramani, Komal and Lopitz-Otsoa, Fernando and Rodríguez, Manuel S. and Li, Tony W. H. and Ko, Kwangsuk and Yang, Heping and Bardag-Gorce, Fawzia and Iglesias-Ara, Ainhoa and Feo, Francesco and Pascale, Rosa Maria and Mato, José M. and Lu, Shelley C. (2010) S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes. Hepatology, Vol. 51 (6), p. 2152-2161. eISSN 1527-3350. Article.

Tomasi, Maria Lauda and Tomasi, Ivan and Ramani, Komal and Pascale, Rosa Maria and Xu, Jung and Giordano, Pasquale and Mato, José M. and Shelly, C. Lu (2012) S-adenosylmethionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers. Hepatology, Vol. 56 (3), p. 982-993. eISSN 1527-3350. Article.

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Urtasun, Raquel and Latasa, María Ujue and Demartis , Maria Ilaria and Balzani, Stella and Goñi, Saioa and Garcia-Irigoyen, Oihane and Elizalde, María and Azcona, María and Pascale, Rosa Maria and Feo, Francesco and Bioulac-Sage, Paulette and Balabaud, Charles and Muntané, Jordi and Prieto, Jesús and Berasain, Carmen and Ávila, Matías A. (2011) Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein–mediated activation. Hepatology, Vol. 54 (6), p. 2149-2158. eISSN 1527-3350. Article.