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Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium

Sanna, Vanna Annunziata and Gavini, Elisabetta and Rassu, Giovanna and Pirisino, Gerolamo Antonio and Giunchedi, Paolo (2006) Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium. In: SardiniaChem 2006: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive, 5 Giugno 2006, Cagliari, Italia. Conference or Workshop Item.

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Abstract

A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon. The aim of this study was the preparation of dry-coated tablets designed for colonic release of the model drug Diclofenac sodium (DS). The system consists of a drug-pectine (PC) mixture as the core and hydroxypropylmethylcellulose (HPMC) alone or mixed in different ratios with poly(ε-caprolactone) (CL) as the coat layer.

Item Type:Conference or Workshop Item (Poster)
ID Code:999
Status:Published
Uncontrolled Keywords:Dry-coated tablets, colonic release, Diclofenac sodium
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Additional Information:Comitato organizzatore di SardiniaChem 2006: Salvatore Cabiddu, Pier Paolo Piras Università di Cagliari; Giovanna Delogu, CNR Sassari; Giampaolo Giacomelli, Università di Sassari.
Deposited On:18 Aug 2009 10:03

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