titoli, abstracts, parole chiave >>>
Impact of first trimester fasting glycemic levels on expression of proteoglycans in pregnancy

Capobianco, Giampiero and De Muro, Pierina and Lepedda, Antonio Junior and Dessole, Margherita and Ambrosini, Guido and Cherchi, Pier Luigi and Formato, Marilena (2014) Impact of first trimester fasting glycemic levels on expression of proteoglycans in pregnancy. Journal of obstetrics and gynaecology research, Vol. 40 (6), p. 1625-1631. ISSN 1341-8076. eISSN 1447-0756. Article.

Full text not available from this repository.

DOI: 10.1111/jog.12411


Aim: The aim of this study was to assess the influence of glucose metabolism on the expression of glycosaminoglycans (GAGs) and proteoglycans (PGs) in pregnant women.
Material and Methods: Seventy-six women in the first trimester of pregnancy (10–13 weeks) attending the Gynecologic and Obstetric Clinic, University of Sassari, were enrolled and gave early morning urine samples. Groups I, II and III included women with serum glucose values of 65–89 mg/dL, 90–99 mg/dL and 100–125 mg/dL, respectively. Urine GAGs/PGs distribution was determined by electrophoresis on cellulose acetate strips. Urinary N-Acetyl-β-glucosaminidase was estimated kinetically.
Results: Analysis of urinary GAGs/PGs electrophoretic profiles showed a significant increase in heparan sulfate (HS) excretion (P = 0.017) as well as a reduced chondroitin sulfate (CS) excretion (P = 0.048) in the group II pregnant women compared with the group I, and higher values of the HS/CS ratio in groups II and III compared to group I. Furthermore, we observed a positive correlation among fasting blood glucose levels and the relative content of HS, the HS/CS and urinary trypsin inhibitor/CS ratios, and the N-Acetyl-β- glucosaminidase levels.
Conclusions: The assessment of risk factors for gestational diabetes mellitus should also take into account fasting blood glucose values of 90–99 mg/dL, as the findings of our study indicated an alteration in the metabolism of GAGs during the early stages of pregnancy.

Item Type:Article
ID Code:9976
Uncontrolled Keywords:Gestational diabetes mellitus, glycosaminoglycans, proteoglycans
Subjects:Area 06 - Scienze mediche > MED/40 Ginecologia e ostetricia
Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Blackwell / Wiley
Copyright Holders:© 2014 The Authors, Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology
Deposited On:17 Jul 2014 12:05

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page