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Genetic susceptibility to multiple sclerosis in Sardinians: an immunological study

Sotgiu, Stefano and Serra, Caterina and Marrosu, Maria Giovanna and Dolei, Antonina and Pugliatti, Maura and Murgia, B. and Aiello, Isidoro Cesare Giuseppe and Rosati, Giulio (1998) Genetic susceptibility to multiple sclerosis in Sardinians: an immunological study. Acta Neurologica Scandinavica, Vol. 98 (5), p. 314-317. ISSN 0001-6314. eISSN 1600-0404. Article.

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DOI: 10.1111/j.1600-0404.1998.tb01740.x

Abstract

Objectives - We studied the in vitro production of variably MS-related cytokines from Sardinian MS and healthy donors bearing the two “Sardinian” MS-associated HLA-DR alleles: DR3 and DR4, with the purpose to evidentiate possible differences in their immune response.
Materials and methods - ELISA were used for detection of cellular products by mitogen-activated peripheral blood mononuclear cells.
Results - PHA-activated HLA-DR4+/DR3- mononuclear cells produce significantly higher amounts of TNF-α compared with the DR3 +/DR4-, In addition, homozygous HLA-DR3+ mononuclear cells from MS patients produce significantly lower amounts of IL-10 than those from homozygous HLA-DR3+ healthy donors. Conclusion - The abnormal production of detrimental or regulatory cytokines may account for the genetic susceptibility to MS in different HLA-subgroups of Sardinian MS patients.

Item Type:Article
ID Code:9968
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, susceptibility, HLA-DR, cytokines, Sardinia
Subjects:Area 06 - Scienze mediche > MED/39 Neuropsichiatria infantile
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
Publisher:Blackwell / Wiley
ISSN:0001-6314
eISSN:1600-0404
Copyright Holders:© Munksguard 1998
Deposited On:15 Jul 2014 10:26

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