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Comparison of selectivity of a family of chelating agents for trivalent (Al3+, Fe3+) and bivalent (Cu2+, Zn2+) metal ions

Toso, Leonardo and Crisponi, Guido and Santos, Maria Amelia and Marques, Sergio M. and Nurchi, Valeria Marina and Lachowicz, Joanna I. and Crespo-Alonso, Miriam and Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco (2014) Comparison of selectivity of a family of chelating agents for trivalent (Al3+, Fe3+) and bivalent (Cu2+, Zn2+) metal ions. In: ISMEC 2013: International symposia on metal complex: acta, 16-20 giugno 2013, Burgos, Spain. [S.l.], ISMEC Group / Universidad de Burgos. p. 94-95. (ISMEC Group Series, 3). ISSN 2239-2459. Conference or Workshop Item.

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Chelation therapy is used for the treatment of metal intoxication in humans. Selectivity towards the target metal ion is one important characteristic of the chelating agent.
In the frame of our research of chelating agents for iron and aluminium, we synthesized five new ligands (Figure 1), and studied their behavior toward the trivalent metal ions. L4, L5, L6 and L8 were found to be excellent ligands for the coordination of Fe3+ and Al3+. We are presenting here a study on the same ligands with the two essential bivalent metal ions, Zn2+ and Cu2+. The results of spectrophotometric, potentiometric, and NMR measurements performed to determine the equilibrium formation constants will be presented. The speciation of the complexes with the trivalent metal ions in presence of endogenous zinc and copper will be discussed.

Item Type:Conference or Workshop Item (Poster)
ID Code:9960
Uncontrolled Keywords:Chelation terapy, metal intoxication, metal ions
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/01 Chimica analitica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:ISMEC Group / Universidad de Burgos
Publisher Policy:Authors retain the copyrights of their acta, and their unrestricted use, distribution and reproduction in any medium are permitted, provided that the original work is properly cited
Deposited On:22 Jul 2014 12:13

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