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D-Penicillamine interferes with S-homocysteinylation and S-cysteinylation of LDL apolipoprotein B

Sotgia, Salvatore and Carru, Ciriaco and Pinna, Gérard Aimé and Deiana, Luca and Zinellu, Angelo (2011) D-Penicillamine interferes with S-homocysteinylation and S-cysteinylation of LDL apolipoprotein B. The Journal of Clinical Pharmacology, Vol. 51 (12), p. 1728-1732. ISSN 0091-2700. eISSN 1552-4604. Article.

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DOI: 10.1177/0091270010385933

Abstract

Modifications of low-density lipoprotein-cholesterol particles (LDLs) are among the principal mechanisms that can play a pivotal role in the initiation and progression of atherosclerosis. It is well known, in fact, that once modified, LDLs increase their atherogenicity, resulting in enhanced uptake by macrophage scavenger receptors that in the long run, leads to the formation of lipid-laden macrophages, or “foam cells,” which are the hallmark of atherosclerotic lesions. Among the atherogenic modifications of LDL, alteration resulting from homocysteinylation of apoB is currently receiving a great deal of attention, as its harmful role is becoming apparent. A type of apoB homocysteinylation, LDL-S-homocysteinylation (Hcy- S-LDL), occurs through the formation of a disulfide bond with protein cysteine residues. Another type, LDL-N-homocysteinylation (Hcy-N-LDL), occurs by post-translational acylation of free amino groups in a reaction mediated by homocysteine thiolactone.

Item Type:Article
ID Code:9953
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cardiovascular (CAR), biochemistry (BIO), clinical pharmacology (CPH), drug delivery (DEL), lipid metabolism (LIP)
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Springer
ISSN:0091-2700
eISSN:1552-4604
Copyright Holders:© 2011 The Author(s)
Deposited On:07 Jul 2014 10:51

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