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Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women

Franconi, Flavia and Campesi, Ilaria (2014) Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women. British journal of pharmacology, Vol. 171 (3), p. 580-594. ISSN 0007-1188. eISSN 1476-5381. Article.

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DOI: 10.1111/bph.12362

Abstract

Pharmacological response depends on multiple factors and one of them is sex–gender. Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and efficacy of numerous medications, are beginning to emerge. Nevertheless, the recruitment of women for clinical research is inadequate, especially during the first phases. In general, pharmacokinetic differences between males and females are more numerous and consistent than disparities in pharmacodynamics. However, sex–gender pharmacodynamic differences are now increasingly being identified at the molecular level. It is now even becoming apparent that sex–gender influences pharmacogenomics and pharmacogenetics. Sex-related differences have been reported for several parameters, and it is consistently shown that women have a worse safety profile, with drug adverse reactions being more frequent and severe in women than in men. Overall, the pharmacological status of women is less well studied than that of men and deserves much more attention. The design of clinical and preclinical studies should have a sex–gender-based approach with the aim of tailoring therapies to an individual's needs and concerns.

Item Type:Article
ID Code:9951
Status:Published
Refereed:Yes
Uncontrolled Keywords:Sex differences, gender differences, drug response, pharmacodynamics, pharmacokinetic
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Wiley
ISSN:0007-1188
eISSN:1476-5381
Copyright Holders:© 2013 The British Pharmacological Society
Additional Information:This article is part of a themed section on Biological Sex and Cardiovascular Pharmacology (Special issue). To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-3.
Deposited On:07 Jul 2014 09:11

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