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Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy

Pacini, Stefania and Giovannelli, Lisa and Gulisano, Massimo and Peruzzi, Benedetta and Polli, Gianni and Boddi, Vieri and Ruggiero, Marco and Bozzo, Corrado Pasquale and Stomeo, Francesco and Fenu, Grazia and Pezzatini, Silvia and Pitozzi, Vanessa and Dolara, Piero (2003) Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy. Environmental and molecular mutagenesis, Vol. 42 (3), p. 127-135. ISSN 0893-6692. eISSN 1098-2280. Article.

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DOI: 10.1002/em.10188

Abstract

We evaluated the effects of urban air pollutants on human nasal mucosa over an 8-month period on 102 subjects living in Florence, Tuscany, Italy. A group of subjects living in a city with a lower level of pollution (Sassari, Sardinia, Italy) was also analyzed. Nasal mucosa cells were harvested by brushing, a noninvasive procedure. Half of the cells were used for genotoxicity studies using the alkaline comet assay, and half for morphological studies. The levels of DNA damage in the nasal mucosa were considerably higher (+73%) in the subjects living in Florence than in Sassari. High levels of atmospheric ozone in Florence air correlated with DNA damage, and to the prevalence of inflammatory pathologies of the upper respiratory tract, although the ozone concentrations were below the Italian recommended attention level. Furthermore, higher levels of DNA damage were correlated with a dysfunction in the ability to maintain a normal epithelial cell structure. These data suggest an association between ozone air levels and damage in the upper respiratory tract. It remains unclear whether ozone itself or other associated pollutants are responsible for the observed alterations.

Item Type:Article
ID Code:9946
Status:Published
Refereed:Yes
Uncontrolled Keywords:Air pollution, respiratory inflammation, comet assay, nasal histology
Subjects:Area 06 - Scienze mediche > MED/31 Otorinolaringoiatria
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Veterinaria
Publisher:Wiley
ISSN:0893-6692
eISSN:1098-2280
Deposited On:03 Jul 2014 10:26

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