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Simultaneous telemetric monitoring of brain glucose and lactate and motion in freely moving rats

Rocchitta, Gaia Giovanna Maria and Secchi, Ottavio and Alvau, Maria Domenica and Farina, Donatella and Bazzu, Gianfranco and Calia, Giammario and Migheli, Rossana and Desole, Maria Speranza and O'Neill, Robert D. and Serra, Pier Andrea (2013) Simultaneous telemetric monitoring of brain glucose and lactate and motion in freely moving rats. Analitycal chemistry, Vol. 85 (21), p. 10282-10288. ISSN 0003-2700. eISSN 1520-6882. Article.

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DOI: 10.1021/ac402071w

Abstract

A new telemetry system for simultaneous detection of extracellular brain glucose and lactate and motion is presented. The device consists of dual-channel, single-supply miniature potentiostat–I/V converter, a microcontroller unit, a signal transmitter, and a miniaturized microvibration sensor. Although based on simple and inexpensive components, the biotelemetry device has been used for accurate transduction of the anodic oxidation currents generated on the surface of implanted glucose and lactate biosensors and animal microvibrations. The device was characterized and validated in vitro before in vivo experiments. The biosensors were implanted in the striatum of freely moving animals and the biotelemetric device was fixed to the animal’s head. Physiological and pharmacological stimulations were given in order to induce striatal neural activation and to modify the motor behavior in awake, untethered animals.

Item Type:Article
ID Code:9917
Status:Published
Refereed:Yes
Uncontrolled Keywords:Telemetry system, brain glucose, lactate, motor behavior, rats
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:American Chemical Society
ISSN:0003-2700
eISSN:1520-6882
Deposited On:25 Jun 2014 11:39

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