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Clinicopathological and molecular findings in a case of canine Anaplasma phagocytophilum infection in Northern Italy

Dondi, Francesco and Russo, Samanta and Agnoli, Chiara and Mengoli, Nicola and Balboni, Andrea and Alberti, Alberto and Battilani, Mara (2014) Clinicopathological and molecular findings in a case of canine Anaplasma phagocytophilum infection in Northern Italy. Scientific World Journal, Vol. 2014 , Article 810587. eISSN 1537-744X. Article.

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DOI: 10.1155/2014/810587


A documented case of canine granulocytic anaplasmosis coupled with the molecular characterization of the etiological agent is reported for the first time in Northern Italy. The patient showed nonspecific clinical signs such as fever and weight loss. The most relevant clinicopathological findings were thrombocytopenia, hypoalbuminemia, and normal azotemic proteinuria consistent with glomerular diseases. Blood smear examination revealed the presence of intracytoplasmatic inclusions in neutrophils associatedwith high positive serology for Anaplasma phagocytophilum. PCR analysis and sequencing of the amplicon confirmserological diagnosis of A. phagocytophilum. Phylogenetic analysis evidenced that the detected bacterial strain belongs to the A. phagocytophilum Europe 1 lineage. Data indicates that A. phagocytophilum circulates in natural environments of Emilia-Romagna region (Northern Italy) and its prevalence in dogs could be underestimated because the clinical signs are frequently nonspecific and a certain diagnosis requires the combination of clinicopathological and molecular assays. Pets living in this area should be regularly monitored and treated for ectoparasites to minimize health risks for humans and pets. Also, surveillance of A. phagocytophilum should be improved in Northern Italy and canine anaplasmosis should be considered in differential diagnosis of persistent proteinuria.

Item Type:Article
ID Code:9896
Uncontrolled Keywords:Canine Anaplasma phagocytophilum, clinicopathological and molecular findings
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/05 Malattie infettive degli animali domestici
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Veterinaria
Publisher:Hindawi Publishing Corporation
Copyright Holders:© 2014 Francesco Dondi et al.
Deposited On:24 Jun 2014 12:43

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