Scicchitano, Pietro and Cameli, Matteo and Maiello, Maria and Modesti, Pietro Amedeo and Muiesan, Maria Lorenza and Novo, Salvatore and Palmiero, Pasquale and Saba, Pier Sergio and Pedrinelli, Roberto and Ciccone, Marco Matteo (2014) Nutraceuticals and dyslipidaemia: beyond the common therapeutics. Journal of functional foods, Vol. 6 , p. 11-32. ISSN 1756-4646. eISSN 2214-9414. Article.
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Dyslipidaemia accelerates the atherosclerotic process and its morbid consequences; statins represent the evidence-based treatment of choice for reducing low-density lipoprotein cholesterol levels and decreasing cardiovascular events. Unfortunately, statins are frequently not available for several reasons, including intolerance, side effects or, simply, patient preference. Nutraceuticals and functional food ingredients that are beneficial to vascular health may represent useful compounds that are able to reduce the overall cardiovascular risk induced by dyslipidaemia by acting parallel to statins or as adjuvants in case of failure or in situations where statins cannot be used. The mechanisms underlying such actions are not fully understood but may be related to reducing 7a-hydroxylase, increasing faecal excretion of cholesterol, decreasing 3-hydroxy-3-methylglutaryl-CoA reductase mRNA levels or reducing the secretion of very low-density lipoprotein. This contribution provides an overview of the mechanism of action of nutraceuticals and functional food ingredients on lipids and their role in the management of lipid disorders.
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