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Activating KIR molecules and their cognate ligands prevail in children with a diagnosis of ASD and in their mothers

Guerini, Franca R. and Bolognesi, Elisabetta and Chiappedi, Matteo and Manca, Salvatorica and Ghezzo, Alessandro and Agliardi, Cristina and Zanette, Michela and Littera, Roberto and Carcassi, Carlo and Sotgiu, Stefano and Clerici, Mario Salvatore (2014) Activating KIR molecules and their cognate ligands prevail in children with a diagnosis of ASD and in their mothers. Brain, behavior, and immunity, Vol. 36 , p. 54-60. ISSN 0889-1591. eISSN 1090-2139. Article.

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DOI: 10.1016/j.bbi.2013.10.006

Abstract

The activity of natural killer (NK) cells is modulated by the interaction between killer-cell immune globulin-like receptor (KIR) proteins and their cognate HLA ligands; activated NK cells produce inflammatory cytokines and mediate innate immune responses. Activating KIR/HLA complexes (aKIR/HLA) were recently suggested to prevail in children with autism spectrum disorders (ASD), a neurodevelopmental syndrome characterized by brain and behavioral abnormalities and associated with a degree of inflammation. We verified whether such findings could be confirmed by analyzing two sample cohorts of Sardinian and continental Italian ASD children and their mothers. Results showed that aKIR/HLA are increased whereas inhibitory KIR/HLA complexes are reduced in ASD children; notably this skewing was even more significant in their mothers. KIR and HLA molecules are expressed by placental cells and by the trophoblast and their interactions result in immune activation and influence fetal, as well as central nervous system development and plasticity. Data herein suggest that in utero KIR/HLA immune interactions favor immune activation in ASD; this may play a role in the pathogenesis of the disease.

Item Type:Article
ID Code:9826
Status:Published
Refereed:Yes
Uncontrolled Keywords:Killer cell immunoglobulin-like receptor, Kir genes, human leukocyte antigens, HLA ligands, autism, natural killer cells, maternal immunity
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Academic Press / Elsevier
ISSN:0889-1591
eISSN:1090-2139
Copyright Holders:© 2013 Elsevier
Deposited On:23 May 2014 13:20

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