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Evaluation of commercial multi-drug oral fluid devices to identify 39 new amphetamine-designer drugs

Nieddu, Maria and Burrai, Lucia and Trignano, Claudia and Boatto, Gianpiero (2014) Evaluation of commercial multi-drug oral fluid devices to identify 39 new amphetamine-designer drugs. Legal Medicine, Vol. 16 (2), p. 106-109. ISSN 1344-6223. eISSN 1873-4162. Article.

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DOI: 10.1016/j.legalmed.2013.12.001

Abstract

Recently, the diffusion on the black market of new psychoactive substances not controlled and often sold as ‘legal highs’, is exponentially increasing in Europe. Generally, the first analysis for these drugs involves an immunoassay screening in urine or plasma. Actually, there is growing interest in the use of oral fluid (OF) as alternative specimen over conventional biological fluids for drug testing, because of the significant advantages, as a non-invasive collection under direct observation without undue embarrassment or invasion of privacy, and a good correlation with plasma analytical data. Few assays have been developed for detection of new psychoactive compounds in biological samples, so it is important to investigate how they may or may not react in pre-existing commercial immunoassays. In this paper, two different multi-drugs oral fluid screen devices (OFDs) (Screen® Multi-Drug OFD and GIMA One Step Multi-Line Screen Test OFD) were evaluated to determine the cross-reactivity of thirty-nine new amphetamine designer drugs, including twelve substances officially recognized as illicit by italian legislation. Cross-reactivity towards most drugs analyzed was <1 in assays targeting amphetamine (AMP) or methamphetamine (MET). Only two (p-methoxyamphetamine and p-methoxymethamphetamine) of all tested amphetamines gave a positive result.

Item Type:Article
ID Code:9815
Status:Published
Refereed:Yes
Uncontrolled Keywords:Oral fluid devices (OFDs), legal highs, amphetamine, designer drugs, immunoassay screening
Subjects:Area 06 - Scienze mediche > MED/43 Medicina legale
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:1344-6223
eISSN:1873-4162
Copyright Holders:© Elsevier Ireland Ltd. All rights reserved
Deposited On:21 May 2014 09:16

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