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Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients

Mameli, Giuseppe and Cossu, Davide and Cocco, Eleonora and Masala, Speranza and Frau, Jessica and Marrosu, Maria Giovanna and Sechi, Leonardo Antonio (2014) Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients. Journal of Neuroimmunology, Vol. 270 (1-2), p. 51-55. ISSN 0165-5728. eISSN 1872-8421. Article.

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DOI: 10.1016/j.jneuroim.2014

Abstract

Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis (MAP) have been associated to multiple sclerosis (MS). We searched for antibodies against the homologous peptides Epstein–Barr virus nuclear antigen 1 (EBNA1)400–413, MAP_0106c protein (MAP)121–132, and myelin basic protein (MBP)85–98 on a MS Sardinian cohort, showing that these antibodies are highly prevalent among MS patients compared to healthy controls. Competitive assay demonstrated that antibodies recognizing EBNA1400–413 and MAP121–132 cross-react with MBP85–98, possibly through a molecular mimicry mechanism. Indeed, the fact that peptides from different pathogens can be cross-recognized by antibodies targeting self-epitopes supports the hypothesis that EBV and MAP might trigger autoimmunity through a common target.

Item Type:Article
ID Code:9767
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, molecular mimicry, Epstein–Barr virus, Mycobacterium avium subsp. paratuberculosis, myelin basic protein
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:0165-5728
eISSN:1872-8421
Deposited On:30 Apr 2014 08:54

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