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Usefulness of magnetic resonance in patients with invasive cancer eligible for breast conservation: a comparative study

Fancellu, Alessandro and Soro, Daniela and Castiglia, Paolo Giuseppino and Marras, Vincenzo and Melis, Marcovalerio and Cottu, Pietrina and Cherchi, Alessandra and Spanu, Angela and Mulas, Silvia and Pusceddu, Claudio and Simbula, Luca and Meloni, Giovanni Battista (2014) Usefulness of magnetic resonance in patients with invasive cancer eligible for breast conservation: a comparative study. Clinical breast cancer, Vol. 14 (2), p. 114-121. ISSN 1526-8209. eISSN 1938-0666. Article.

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DOI: 10.1016/j.clbc.2013.10.002

Abstract

In this comparative study, magnetic resonance imaging (MRI) of the breast altered the treatment plan in 16.5% of patients with breast cancer who were candidates for breast conservation. MRI was associated with higher mastectomy rates compared with a conventional preoperative workup but did not reduce reoperation rates for positive margins. Lymph node positivity and tumor size < 15 mm may predict an MRI-triggered change of surgical plan.
Background: The role of magnetic resonance imaging (MRI) in newly detected breast cancer remains controversial. We investigated the impact of preoperative MRI on surgical management of infiltrating breast carcinoma (IBC).
Methods: We reviewed data of 237 patients with IBC who were suitable for breast-conserving surgery (BCS) between 2009 and 2011. Of these patients, 109 underwent preoperative MRI (46%; MRI group) and 128 did not (54%; no-MRI group). We analyzed MRI-triggered changes in surgical plan and compared differences in rates of positive margins and mastectomy.
Results: Tumor size was larger in the MRI group (16.8 mm vs. 13.9 mm; P < .001). MRI changed the initial surgical planning in 18 of 109 patients (16.5%) because of detection of larger tumor diameter requiring wider resection (8 patients [7.3%]) or additional malignant lesions in the ipsilateral (9 patients [8.2%]) or contralateral breast (1 patient [0.9%]). MRI-triggered treatment changes included mastectomy (n = 12), wider excision (n = 5), and contralateral BCS (n = 1). Reoperation rates for positive margins after BCS appeared higher in the no-MRI group (4.1% vs. 8.6%), but the difference missed statistical significance (P = .9). Overall mastectomy rates were higher in the MRI group (13.7% vs. 7.0%; P < .05). The likelihood of having a change of treatment resulting from MRI was significantly higher for patients with tumors > 15 mm and for those with positive lymph nodes.
Conclusion: Lymph node positivity and tumor size > 15 mm may predict an MRI-triggered change in surgical plan. Preoperative MRI resulted in higher mastectomy rates justified by biopsy-proven additional foci of carcinoma and did not significantly reduce reoperation rates for positive margins.

Item Type:Article
ID Code:9685
Status:Published
Refereed:Yes
Uncontrolled Keywords:Breast-conserving surgery, breast cancer treatment, invasive carcinoma, magnetic resonance imaging, margins
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier
ISSN:1526-8209
eISSN:1938-0666
Deposited On:19 Mar 2014 11:06

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