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Molecular identification of Mycobacterium avium subspecies paratuberculosis in oral biopsies of Crohn’s disease patients

Molicotti, Paola and Scanu, Antonio Mario and Lumbau, Aurea Maria Immacolata and Cannas, Sara and Bua, Alessandra and Lugliè, Pietrina Francesca and Zanetti, Stefania Anna Lucia (2013) Molecular identification of Mycobacterium avium subspecies paratuberculosis in oral biopsies of Crohn’s disease patients. Gut Pathogens, Vol. 5 (18). eISSN 1757-4749. Article.

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DOI: 10.1186/1757-4749-5-18

Abstract

Oral lesions may be found in patients with Crohn’s disease (CD), in a percentage up to 20%. The aim of this study was to investigate a possible relationship between Mycobacterium avium subsp. paratuberculosis (MAP) and oral lesions in CD patients. 23 oral biopsies were examined performing IS900 Nested PCR; 9 of them were positive: 8 from CD patients and 1 from a control. Our purpose is to go on with this study, amplifying the number of subjects examined and testing subjects with oral lesions related to diseases other than CD to verify the specific association between MAP and oral lesions in CD patients.

Item Type:Article
ID Code:9645
Status:Published
Refereed:Yes
Uncontrolled Keywords:MAP, oral lesion Crohn, oral granulomatous lesions, PCR IS900
Subjects:Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:BioMed Central
eISSN:1757-4749
Copyright Holders:© 2013 Molicotti et al; licensee BioMed Central Ltd.
Deposited On:26 Feb 2014 10:57

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