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Intravitreal steroids for the treatment of retinal diseases

Sarao, Valentina and Veritti, Daniele and Boscia, Francesco and Lanzetta, Paolo (2014) Intravitreal steroids for the treatment of retinal diseases. Scientific World Journal, Vol. 2014 (2014), p. 989501. eISSN 1537-744X. Article.

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DOI: 10.1155/2014/989501

Abstract

Diabetic macular edema (DME), pseudophakic cystoid macular edema (CME), age-related macular degeneration (AMD), retinal vascular occlusion (RVO), and uveitis are ocular conditions related to severe visual impairment worldwide. Corticosteroids have been widely used in the treatment of these retinal diseases, due to their well-known antiangiogenic, antiedematous, and anti-inflammatory properties. Intravitreal steroids have emerged as novel and essential tools in the ophthalmologist’s armamentarium, allowing for maximization of drug efficacy and limited risk of systemic side effects. Recent advances in ocular drug delivery methods led to the development of intraocular implants, which help to provide prolonged treatment with controlled drug release. Moreover, they may add some potential advantages over traditional intraocular injections by delivering certain rates of drug directly to the site of action, amplifying the drug’s half-life, contributing in the minimization of peak plasma levels of the drug, and avoiding the side effects associated with repeated intravitreal injections. The purpose of this review is to provide an update on the use of intravitreal steroids as a treatment option for a variety of retinal diseases and to review the current literature considering their properties, safety, and adverse events.

Item Type:Article
ID Code:9632
Status:Published
Refereed:Yes
Uncontrolled Keywords:Diabetic macular edema (DME), pseudophakic cystoid macular edema (CME), age-related macular degeneration (AMD), retinal vascular occlusion (RVO), intravitreal steroids, retinal diseases
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
Publisher:Hindawi Publishing Corporation
eISSN:1537-744X
Copyright Holders:© 2014 Valentina Sarao et al.
Deposited On:14 Apr 2014 10:36

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