titoli, abstracts, parole chiave >>>
The Association of childhood asthma and Helicobacter pylori infection in Sardinia

Dore, Maria Pina and Massidda, Marco and Meloni, Gianfranco and Soro, Sara and Pes, Giovanni Mario and Graham Yates, David (2014) The Association of childhood asthma and Helicobacter pylori infection in Sardinia. Archives of Pediatric Infectious Diseases, Vol. 2 (1), e14202. ISSN 2322-1828. eISSN 2322-1836. Article.

Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Available under License Creative Commons Attribution.


DOI: 10.5812/pedinfect.14202


Background: It has been suggested that Helicobacter pylori infection might reduce the risk of atopic conditions, such as asthma, in childhood. This risk reduction could relate to the “hygiene hypothesis” which proposes an association between childhood exposure to microbes and risk of atopy.
Objectives: To examine the association between Hp infection and childhood acquired asthma in Sardinia.
Patients and Methods: Children from Northern Sardinia who were between the ages of 10 months to 6 years and were screened for Hp infection in 1994-1995 using IgG serology, were asked in 2012, whether they had developed asthma and/or allergic disease in pediatric age, using the global initiative on asthma guidelines questionnaire.
Results: A total of 64 children participated in the study. The sero-positivity for Hp infection was 14.1%. Eleven (17.2%) children had a confirmed diagnosis of asthma with onset before the age of 5 years, 85.9% were Hp negative and 14.1% Hp positive. Eight children of the 53 without asthma were Hp positive (15%) compare to one children positive for the infection of the 11 patients (0.09%) with asthma (8/53 vs. 1/11; P = 0.6). The majority of children (73%) were from urban areas and 43.8% had a family history of asthma or allergies. Multiple logistic regression analysis was not able to find a studied variable, including Hp infection, significantly associated with pediatric asthma.
Conclusions: Our results speak against Hp infection itself playing a role to protect from the risk to develop childhood asthma although household hygiene was not directly assessed.

Item Type:Article
ID Code:9626
Uncontrolled Keywords:Child, asthma, Helicobacter pylori
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Area 06 - Scienze mediche > MED/12 Gastroenterologia
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Kowsar Corporation
Copyright Holders:© Pediatric Infections Research Center
Deposited On:17 Feb 2014 10:38

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page