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A Natural formulation increases brain resistance to oxidative stress

Menghini, Luigi and Ferrante, Claudio and Leporini, Lidia and Pintore, Giorgio Antonio Mario and Chiavaroli, Annalisa and Shohreh, Rugia and Recinella, Lucia and Orlando, Giustino and Vacca, Michele and Brunetti, Luigi (2014) A Natural formulation increases brain resistance to oxidative stress. European journal of medicinal plants, Vol. 4 (2), p. 171-182. eISSN 2231-0894. Article.

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Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain.
Methodology: In the present work we evaluated the effects of a natural formula containing bacopa extract, vitamin E, astaxanthin and phosphatidylserine on lipoperoxidation in rat brain cortex, both in vivo and in vitro.
Results: The results demonstrate that the natural formula could reduce basal and hydrogen peroxide- and amyloid β peptide-induced oxidative stress, as evidenced by the reduction of 8-iso-PFG and ROS/RNS production in the rat brain.
Conclusion: Results could account for a rational use of herbal products in the treatment of conditions characterized by increased burden of oxidative stress and defective antioxidant mechanisms, such as aging and neurodegenerative disorders.

Item Type:Article
ID Code:9625
Uncontrolled Keywords:Oxidative stress, Bacopa, Astaxanthin, vitamin E, phosphatidylserin, hydrogen peroxide, amyloid β-peptide
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Sciencedomain International
Copyright Holders:© 2014 Menghini et al.
Deposited On:17 Feb 2014 09:53

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