Menghini, Luigi and Ferrante, Claudio and Leporini, Lidia and Pintore, Giorgio Antonio Mario and Chiavaroli, Annalisa and Shohreh, Rugia and Recinella, Lucia and Orlando, Giustino and Vacca, Michele and Brunetti, Luigi (2014) A Natural formulation increases brain resistance to oxidative stress. European journal of medicinal plants, Vol. 4 (2), p. 171-182. eISSN 2231-0894. Article.
Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain.
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