Talamonti, Cinzia and Reggioli, Valentina and Bruzzi, Mara and Bucciolini, Marta and Civinini, Carlo and Marrazzo, Livia and Menichelli, David and Pallotta, Stefania and Randazzo, Nunzio and Sipala, Valeria and Cirrone, Giuseppe Antonio Pablo and Petterson, M. and Blumenkrantz, Nate and Feldt, Jason and Heimann, Jason and Lucia, Dominic and Seiden, Abe and Williams, David C. and Sadrozinski, Hartmut F.W. and Bashkirov, Vladimir A. and Schulte, Reinhard (2010) Proton radiography for clinical applications. Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 612 (3), p. 571-575. ISSN 0168-9002. eISSN 1872-9576. Article.
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Proton imaging is not yet applied as a clinical routine, although its advantages have been demonstrated. In the context of quality assurance in proton therapy, proton images can be used to verify the correct positioning of the patient and to control the range of protons. Proton computed tomography (pCT) is a 3D imaging method appropriate for planning and verification of proton radiation treatments, because it allows evaluating the distributions of proton stopping power within the tissues and can be directly utilized when the patient is in the actual treatment position. The aim of the PRoton IMAging experiment, supported by INFN, and the PRIN 2006 project, supported by MIUR, is to realize a proton computed radiography (pCR) prototype for reconstruction of proton images from a single projection in order to validate the technique with pre-clinical studies and, eventually, to conceive the configuration of a complete pCT system. A preliminary experiment performed at the 250 MeV proton synchrotron of Loma Linda University Medical Center (LLUMC) allowed acquisition of experimental data before the completion of PRIMA project's prototype. In this paper, the results of the LLUMC experiment are reported and the reconstruction of proton images of two phantoms is discussed.
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