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Allestimento di un vaccino a DNA contro Mycoplasma agalactiae

Chessa, Bernardo (2009) Allestimento di un vaccino a DNA contro Mycoplasma agalactiae. Doctoral Thesis.

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Abstract

A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both Th1 and Th2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases.

Item Type:Doctoral Thesis
ID Code:958
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Mycoplasma agalactiae, vaccini a DNA, Sardegna
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/05 Malattie infettive degli animali domestici
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
Cicli, scuole e corsi:Ciclo 20 > Corsi > Biochimica, biologia e biotecnologie molecolari
Deposited On:18 Aug 2009 10:03

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