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Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of proximal type epithelioid sarcomas: report of two cases

Cossu, Antonio and Paliogiannis, Panagiotis and Capobianco, Giampiero and Sini, Maria Cristina and Dessole, Margherita and Dessole, Salvatore and Palmieri, Giuseppe (2013) Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of proximal type epithelioid sarcomas: report of two cases. European Journal of Gynaecological Oncology, Vol. 34 (5), p. 469-472. ISSN 0392-2936. Article.

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Abstract

Epithelioid sarcomas (ES) are rare soft issue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Recently, immunohistological detection of Ca 125 was described in ES, as well as loss of INI 1 expression. The authors describe in this paper the morphological and immunohistochemical features of two cases of priximal ES of the vulva. Immunoreactivity for CA 125 and loss of INI 1 expression were present in both cases. These results confirm previous observations in Asian reports showing that these markers can be used as immunohistochemical markers for the diagnostic assessment of ES.

Item Type:Article
ID Code:9546
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cancer, vulva, epithelioid sarcoma, Ca 125, immunochemistry
Subjects:Area 06 - Scienze mediche > MED/40 Ginecologia e ostetricia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari > Unità genetica dei tumori
Publisher:IROG Canada
ISSN:0392-2936
Deposited On:08 Jan 2014 17:31

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