Cossu, Antonio and Paliogiannis, Panagiotis and Capobianco, Giampiero and Sini, Maria Cristina and Dessole, Margherita and Dessole, Salvatore and Palmieri, Giuseppe (2013) Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of proximal type epithelioid sarcomas: report of two cases. European Journal of Gynaecological Oncology, Vol. 34 (5), p. 469-472. ISSN 0392-2936. Article.
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Epithelioid sarcomas (ES) are rare soft issue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Recently, immunohistological detection of Ca 125 was described in ES, as well as loss of INI 1 expression. The authors describe in this paper the morphological and immunohistochemical features of two cases of priximal ES of the vulva. Immunoreactivity for CA 125 and loss of INI 1 expression were present in both cases. These results confirm previous observations in Asian reports showing that these markers can be used as immunohistochemical markers for the diagnostic assessment of ES.
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