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Contributo dei potenziali evento-correlati (ERPs) e della scintigrafia cerebrale di perfusione (SPECT) 99mTc-HMPAO nella diagnosi clinica e neuropsicologica dei pazienti con Mild Cognitive Impairment (MCI)

Sanna, Giovanna (2014) Contributo dei potenziali evento-correlati (ERPs) e della scintigrafia cerebrale di perfusione (SPECT) 99mTc-HMPAO nella diagnosi clinica e neuropsicologica dei pazienti con Mild Cognitive Impairment (MCI). Doctoral Thesis.

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Abstract

Aim: The aim was to evaluate the contribution of cerebral perfusion SPECT data and ERPs recording as tools to serve the neuropsychological and clinical diagnosis in Mild Cognitive Impairment (MCI).
Methods: Forty-three patients (age 66.4±7.6; 12 men; MMSE 27.1±2.3; education 10.7±4.1) performed a selective neuropsychological battery to assess general cognitive status, short- and long-term verbal memory, general intelligence, constructional praxia and verbal fluency. All patients underwent ERPs recordings (N400 and P300) and 99mTcHMPAO SPECT.
Results: Pathological performances were recorded in the following neurological tests: Rey Auditory Verbal Learning Test (45.0%), FAB (42.9%), Verbal Span (39.5%), Prose Recall (37.2%). The P300 and N400 were altered in 39.5% and 85.0% of the patients tested, respectively. Overall, a significantly higher regional hypoperfusion incidence was detected in all patients with a special interest of the limbic lobe bilaterally, the left frontal lobe (BA6,8,9,44) and of the left temporal lobe (BA20,22,38).
Conclusion: According to our findings, MCI subjects show a significantly altered ERPs and SPECT pattern: the functional impairment is likely to precede detectable structural changes and cognitive deficit. Thus, the use of ERPs and SPECT might be considered as a valuable tool for clinicians to longitudinally screen and monitor subjects with memory disorders, so an early diagnosis of MCI might be able to predict the conversion from MCI to dementia.

Item Type:Doctoral Thesis
ID Code:9471
Contributors:Piras, Maria Rita
Publisher:Università degli Studi di Sassari
Uncontrolled Keywords:Mild Cognitive Impairment, ERPs, SPECT
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Cicli, scuole e corsi:Ciclo 26 > Scienze biomediche > Neuroscienze
Deposited On:03 Apr 2014 08:24

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