Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor ntiretroviral regimens failed

Perno, Carlo Federico and Cozzi-Lepri, Alessandro and Forbici, Federica and Bertoli, Ada and Violin, Michela and Mura, Maria Stella Anna and Cadeo, Giampiero and Orani, Anna and Chirianni, Antonio and De Stefano, Carlo and Balotta, Claudio and Antonella, D'Arminio Monforte (2004) Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor ntiretroviral regimens failed. The Journal of Infectious Diseases, Vol. 189 (11), p. 1983-1987. ISSN 0022-1899. Article.

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DOI: 10.1086/386307

Abstract

The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93 previously drug-naive patients experiencing failure of their first PI-based antiretroviral regimens. In logistic regression analysis, the probability of accumulating a new 90M mutation at virological failure was associated with the presence at baseline of minor mutation 36I (naturally occurring in ∼25% of HIV clade B and in >80% of HIV non-clade-B viruses) (adjusted odds ratio, 13.5 [95% confidence interval, 1.89–95.6]; P=.009) and, possibly, of 10I/V. This suggests a potential role for the presence of 36I at baseline in predicting the appearance of 90M at virological failure.

Item Type:	Article
ID Code:	944
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	HIV protease, 90M mutation, protease-inhibitor, antiretroviral therapy
Subjects:	Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:	001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:	University of Chicago Press
ISSN:	0022-1899
Copyright Holders:	© 2004 by the Infectious Diseases Society of America
Publisher Policy:	Depositato in conformità con la politica di copyright dell'Editore
Deposited On:	18 Aug 2009 10:03

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