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L'Accuratezza diagnostica del bioscanner TRIMPROB: uno strumento non invasivo per la diagnosi delle lesioni pre-neoplastiche del colon: uno studio prospettico in doppio cieco

Tufano, Onofrio Marcello (2014) L'Accuratezza diagnostica del bioscanner TRIMPROB: uno strumento non invasivo per la diagnosi delle lesioni pre-neoplastiche del colon: uno studio prospettico in doppio cieco. Doctoral Thesis.

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Abstract

Aim: A new electromagnetic technology, aimed to the cancer diagnosis, as available in the last years literature, could be a promising non invasive method for detection of colon diseases including cancer . The encouraging published data, regarding specificity and sensitivity of the Nonlinear Resonance Interaction capabilities to analyze some peculiar electromagnetic properties of cancerous vs. normal tissues, related to various clinical trials on prostate, bladder, breast, thyroid, rectum cancer calls for further diagnostic application trials.
Methods: This was a single-centre pilot study. Before colonoscopy, each patient was screened with the TRIMprobe for colonic lesions by an operator in blind. The TRIMprob was moved over the surface of the abdomen area, with the patient standing, normally dressed, between the operator and the system receiver. The signal variation of 3 spectral lines, for 465-MHz, 930-MHz, and 1395-MHz frequencies were recorded. The different anisotropy reveals abnormal tissues. Biopsies collected during colonoscopy were used as Gold Standard. Statistical analysis was performed by chi-squared test.
Results: A total of 91 consecutive patients (mean age: 56 years) undergoing colonoscopy were enrolled. The TRIMprob was able to detect colonic neoplasms in all patients (5/5). Sensitivity, specificity and accuracy of the Bioscanner compared to the histological examination were 100 %, 100 %, and 100 %, respectively. The concordance of the results of the two tests was highly significant (p < 0.0001).
Conclusion: Although these preliminary results need to be verified and extended in routine clinical setting, simplicity and the high diagnostic yield of the TRIMprob suggest that this method should be suitable as a first-level screening tool in detecting colorectal lesions.

Item Type:Doctoral Thesis
ID Code:9408
Contributors:Dore, Maria Pina
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:TRIMPROB, lesioni preneoplastiche, colon
Subjects:Area 06 - Scienze mediche > MED/12 Gastroenterologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 25 > Scuole > Scienze biomediche > Fisiopatologia medica
Deposited On:03 Apr 2014 09:46

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