titoli, abstracts, parole chiave >>>
Axillary lymph node dissection in patients with breast cancer and sentinel lymph node micrometastasis or isolated tumor cells: is it necessary?

Attene, Federico and Paliogiannis, Panagiotis and Scognamillo, Fabrizio and Trignano, Emilio and Pala, Carlo and Trignano, Mario (2012) Axillary lymph node dissection in patients with breast cancer and sentinel lymph node micrometastasis or isolated tumor cells: is it necessary? Tumori, Vol. 98 (3), p. 320-323. ISSN 0300-8916. Article.

Full text not available from this repository.

DOI: 10.1700/1125.12399

Abstract

Aims and background. Sentinel lymph node biopsy is the standard method for axillary lymph node staging in patients with early stage breast cancer. The aim of the study was to evaluate the necessity of axillary lymph node dissection in patients with breast cancer and sentinel lymph node micrometastasis or isolated tumor cells.
Methods. Sentinel lymph node biopsy was performed in 136 patients for breast cancer staging: 16 of them (11.7%) were found to have micrometastasis or isolated tumor cells and underwent axillary lymph node dissection. Micrometastases were considered when tumor invasion was ≤2 mm and >0.2 mm in diameter and isolated tumor cells when detected alone or in clusters of <0.2 mm in diameter. The dissection of the three axillary lymph node levels of Berg was performed in all cases.
Results. Two patients (12.5%) presented isolated tumor cells and 14 (87.5%) micrometastasis in the sentinel lymph node. Among them, 25% presented nonsentinel axillary lymph node tumor invasion, whereas 75% had no further nodal involvement.
Conclusions. Results suggest that micrometastasis or isolated tumor cells of the sentinel lymph node represent the only site of cancer involvement of the axilla, especially in patients with early breast tumors, and that axillary lymph node dissection may be unnecessary in these cases and represent an overtreatment.

Item Type:Article
ID Code:9367
Status:Published
Refereed:Yes
Uncontrolled Keywords:Breast cancer, axillary lymph node dissection, sentinel lymph node biopsy, micrometastasis, isolated tumor cells
Subjects:Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
Publisher:II Pensiero scientifico editore
ISSN:0300-8916
Deposited On:04 Dec 2013 11:19

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page