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La Triplice terapia con estriolo intravaginale, lattobacilli acidophili e riabilitazione del pavimento pelvico nelle pazienti in postmenopausa con disturbi urogenitali

Ashqar, Nimr (2014) La Triplice terapia con estriolo intravaginale, lattobacilli acidophili e riabilitazione del pavimento pelvico nelle pazienti in postmenopausa con disturbi urogenitali. Doctoral Thesis.

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Objective: To assess the effects of the combination of pelvic floor rehabilitation, intravaginal estriol and lactobacillus acidophli administration on stress urinary incontinence (SUI), urogenital atrophy and recurrent urinary tract infections in postmenopausal women.
Methods: 136 postmenopausal women with urogenital aging symptoms were enrolled in this prospective randomized study. Patients: randomly divided into two groups and each group consisted of 68 women. Interventions: Subjects in the triple therapy (group I) received 1 intravaginal ovule containing 30 mcg estriol and lactobacilli acidophili (50 mg lyophilisate containing at least 100 milion live bacteria) such as once daily for 2 weeks and then 2 ovules once weekly for a total of 6 months as maintenance therapy plus pelvic floor rehabilitation. Subjects in the group II received one intravaginal estriol ovule (1 mg) plus pelvic floor rehabilitation in a similar regimen. Mean outcome measures: We evaluated urogenital symptomatology, urine coltures, colposcopic findings, urethral cytologic findings, urethral pressure profiles and urethrocystometry before, as well as after 6 months of treatment.
Results: After therapy, the symptoms and signs of urogenital atrophy significantly improved in both groups. 45/59 (76.27%) of the group I, and 26/63 (41.27%) of the group II referred a subjective improvement of their incontinence. In the patients treated by triple therapy with lactobacilli, estriol plus pelvic floor rehabilitation, we observed significant improvements of colposcopic findings, and there were statistically significant increases in mean maximum urethral pressure (MUP), in mean urethral closure pressure (MUCP), as well as in the abdominal pressure transmission ratio to the proximal urethra (PTR).
Conclusions: Our results showed that triple therapy with lactobacilli acidophili, estriol plus pelvic floor rehabilitation was effective and should be considered as first-line treatment for symptoms of urogenital aging in postmenopausal women.

Item Type:Doctoral Thesis
ID Code:9358
Contributors:Dessole, Salvatore
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:Estriolo intravaginale, lattobacillo acidophili, disturbi urogenitali
Subjects:Area 06 - Scienze mediche > MED/40 Ginecologia e ostetricia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 26 > Scienze biomediche > Scienze Uroginecologiche di fisiopatologia del pavimento pelvico ed infertilità maschile
Deposited On:01 Apr 2014 13:40

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