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Il Contributo della vitamina D nel rischio di sclerosi multipla attraverso la dieta: studio caso-controllo basato su popolazione

Leoni, Stefania (2014) Il Contributo della vitamina D nel rischio di sclerosi multipla attraverso la dieta: studio caso-controllo basato su popolazione. Doctoral Thesis.

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Abstract

Aim: Vitamin D has a key role in MS, by preventing and repairing the myelin damage. Its deficiency is due to lack of sun exposure, diet patterns or a low supplementation. An adequate dietary intake of vitD during adolescence is reported to be protective.
Methods: The international multicentre case–control study of environmental risk factors in MS (EnvIMS Study) aimed to examine the effect of past exposures (diet, sunlight and lifestyle) on the disease risk. An ad hoc postal self-administered questionnaire was used to record exposure to food items in teenage. The intake of vitD was computed by multiplying the amount in a portion by the frequency of intake.
Results: Among 1991 Italian participants (684 cases, 1307 controls) an inverse association was found between MS and consumption of fish/seafood (OR=0.80; 95%IC 0.65-0.97), in particular anchovies and sardines (0.60; 0.40-0.90), mackerel (0.66; 0.48-0.92), and with smoked meat (0.74; 0.58-0.95) and yogurt (0.80; 0.65-0.98) (adjusted for sex, smoke habit, sun exposure and vitD supplementation). A higher estimated overall mean (±SD) intake of vitD was reported in controls vs cases, and through fish consumption.
Conclusions: Dietary patterns show differences between MS patients and age-/sex-matched controls. A higher overall intake of vitD was reported in controls than in cases likely reflecting more frequent consumption of vitD rich fish.
Acknowledgements: FISM 2007/R/14, 2008/R/19.

Item Type:Doctoral Thesis
ID Code:9323
Contributors:Pugliatti, Maura
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:Multiple Sclerosis, diet, vitamin D
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 26 > Scienze biomediche > Neuroscienze
Deposited On:01 Apr 2014 09:58

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