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Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells

Sanna, Vanna Annunziata and Pala, Nicolino and Nurra, Salvatore and Marceddu, Salvatore and Pathani, Divya and Nearnati, Nouri and Sechi, Mario (2013) Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells. In: 35. Convegno della Divisione di chimica organica della Società Chimica Italiana, 9-13 settembre 2013, Sassari, Italia. [S.l.], Società Chimica Italiana, Divisione di chimica organica. P45. Conference or Workshop Item.

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Abstract

Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.
Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding and b) the in vitro antiproliferative efficacy against a panel of PaCa cells.

Item Type:Conference or Workshop Item (Poster)
ID Code:9291
Status:Published
Uncontrolled Keywords:Pancreatic cancer, nanoparticles, peptides
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di scienze delle produzioni alimentari, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Società Chimica Italiana, Divisione di chimica organica
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:05 Nov 2013 09:02

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