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The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors

Pala, Nicolino and Micheletto, Laura and Ihm, Simone and Carta, Fabrizio and McKenna, Robert and Supuran, Claudiu T. and Sechi, Mario (2013) The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors. In: La parola ai giovani: 12. [Convegno]: abstract book, 27 settembre 2013, Cagliari, Italia. [S.l.], Società Chimica Italiana. p. 20. Conference or Workshop Item.

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Abstract

The Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4-substituted-lH-l,2,3-triazol-lyl) benzenesulfonamides. Design and synthesis strategies, x-ray derived CA-ligand binding mode and enzyme-based inhibition results will be presented.

Item Type:Conference or Workshop Item (Poster)
ID Code:9280
Status:Published
Uncontrolled Keywords:Zinc enzymes, Carbonic Anhydrases (CAs), Zinc Binding Function (ZBF)
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Società Chimica Italiana
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:04 Nov 2013 13:08

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