Pala, Nicolino and Micheletto, Laura and Ihm, Simone and Carta, Fabrizio and McKenna, Robert and Supuran, Claudiu T. and Sechi, Mario (2013) The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors. In: La parola ai giovani: 12. [Convegno]: abstract book, 27 settembre 2013, Cagliari, Italia. [S.l.], Società Chimica Italiana. p. 20. Conference or Workshop Item.
Alternative URLs: AbstractThe Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4-substituted-lH-l,2,3-triazol-lyl) benzenesulfonamides. Design and synthesis strategies, x-ray derived CA-ligand binding mode and enzyme-based inhibition results will be presented.
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