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Identification of Trichomonas vaginalis alpha-actinin as the most common immunogen recognized by sera of women exposed to the parasite

Addis, Maria Filippa and Rapelli, Paola and Pinto de Andrade, Ana Maria and Madeira Rita, Fatima and Colombo, Mauro Maria and Cappuccinelli, Pietro Antonio and Fiori, Pier Luigi (1999) Identification of Trichomonas vaginalis alpha-actinin as the most common immunogen recognized by sera of women exposed to the parasite. The Journal of Infectious Diseases, Vol. 180 (5), p. 1727-1730. ISSN 0022-1899. Article.

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DOI: 10.1086/315095

Abstract

A study on presence of antibodies to Trichomonis vaginalis in serum was done on a group of 500 pregnant, asymptomatic Angolan women. A serologic screening, done by ELISA, revealed that 41% of the women had IgG and IgM against the parasite. Analysis of sera by immunoblotting revealed that 94.4% of sera with anti-T. vaginalis IgG class antibodies were reactive against a common immunogenic protein of 115 kDa. The common immunogen was identified as the protozoan α-actinin. All sera recognizing the 115-kDa antigen were reactive against both native and recombinant T. vaginalis α-actinin and nonreactive against human α-actinin. The findings presented in this work offer a new tool for epidemiologic studies and open new perspectives for vaccination.

Item Type:Article
ID Code:928
Status:Published
Refereed:Yes
Uncontrolled Keywords:Trichomonas vaginalis, binding protein, pregnancy, Trichomoniasis, serology, humoral immunity, immunoglobulins, ELISA assay, parasitosis, sexually transmitted disease
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:University of Chicago Press
ISSN:0022-1899
Copyright Holders:© 1999 by the Infectious Diseases Society of America
Publisher Policy:Depositato in conformità con la politica di copyright dell'Editore
Deposited On:18 Aug 2009 10:03

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