Peana, Massimiliano Francesco and Zoroddu, Maria Antonietta and Medici, Serenella and Remelli, Maurizio (2013) The Role of Y-PARK9 protein in preventing manganese-induced Parkinson's disease. In: La parola ai giovani: 12. [Convegno]: abstract book, 27 settembre 2013, Cagliari, Italia. [S.l.], Società Chimica Italiana. p. 7. Conference or Workshop Item.
A variety of metals are essential trace elements but can reach localized toxic concentrations through various disease processes or environmental exposures and have been implicated as having a role in neurodegeneration. In particular, chronic inorganic manganese exposure causes selective toxicity to the nigrostriatal dopaminergic system, resulting in a Parkinsonian-like neurological condition known as Manganism. YPK9 gene (Yeast PARK9; also known as YOR291W) encodes a transmembrane P-type transport ATPase presumably involved in metal coordination and transportation, though its substrate specificity still remains unknown. Mutations in the human homolog of YPK9, PARK9 (ATP13A2), have been linked to genetic forms of early onset parkinsonism. Recently a strong genetic interaction between YPK9 and another Parkinson's disease protein, α-synuclein, has been evidenced in multiple model systems, indicating a crucial role for YPK9 in manganese detoxification in yeast and a specific protecting effect against manganese poisoning [1,3].
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