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Role of SH levels and markers of immune response in the stroke

Musumeci, Maria and Sotgiu, Stefano and Persichilli, Silvia and Arru, Giannina and Angeletti, Silvia and Fois, Maria Laura and Minucci, Angelo and Musumeci, Salvatore (2013) Role of SH levels and markers of immune response in the stroke. Disease Markers, Vol. 35 (3), p. 141-147. ISSN 0278-0240. Article.

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DOI: 10.1155/2013/246205

Abstract

Background. Sulfhydryl groups (SH) are considered a key factor in redox sensitive reaction of plasma, and their modification could be considered an expression of abnormal generation of oxygen free radicals.
Methods. Fifty consecutive patients with acute brain stroke were enclosed in this study. The plasma concentrations of SH groups were correlated to cytokines (IL-1b, IL-6, IL-8, TNF-α), plasma chitotriosidase (Chit), metalloprotease (MMP2–9), intercellular adhesion molecule-1 (ICAM-1). Results. The results demonstrated a significant reduction of SH groups within 24 hours from the onset of an acute ischemic stroke, a reduction of plasma IL-1b, IL-6, and IL-8, and an increase of Chit and TNF-α in relation to the stroke severity.
Conclusion. The observation of an intense microenvironment activation that follows the stroke and the correlation between SH levels and markers of immune response suggest that, especially in stroke, is necessary to maintain the redox function to prevent the brain damage. The reduced SH levels represent an attempt to neutralize the abnormal generation of free radicals. Since the reperfusion of brain after ischemic event represents a severe oxidative stress, which must be corrected by regeneration of redox sensitive function, pharmacological intervention could be beneficial in this setting.

Item Type:Article
ID Code:9246
Status:Published
Refereed:Yes
Uncontrolled Keywords:Sulfhydryl groups (SH), SH levels and markers, plasma concentrations
Subjects:Area 06 - Scienze mediche > MED/39 Neuropsichiatria infantile
Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:IOS Press
ISSN:0278-0240
Copyright Holders:© 2013 Maria Musumeci et al.
Deposited On:03 Oct 2013 10:36

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