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Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified: cyclodextrins

Burrai, Lucia and Nieddu, Maria and Pirisi, Maria Antonietta and Carta, Antonio and Briguglio, Irene and Boatto, Gianpiero (2013) Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified: cyclodextrins. Chirality, Vol. 25 (10), p. 617-621. eISSN 1520-636X. Article.

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DOI: 10.1002/chir.22185

Abstract

An easy-to-prepare chiral CE method for the enantiomeric separation of 13 new amphetamine-like designer drugs, using CDs as chiral selectors, was developed. Sulfated-β-CD was found to be the best chiral selector among the three used (sulfated-β-CD, caroboxymethyl-β-CD, dimethyl-β-CD). The separation of the analytes was achieved in a fused-silica gel capillary at 20 °C using an applied voltage of +25 kV. The optimized background electrolyte consisted of 63.5 mM H3PO4 and 46.9 mM NaOH in water. Several electrophoretic parameters such as CD type, CD concentration (1 - 40 mg/mL), buffer pH (2.6, 3.6, 5.0, 6.0), length of the capillary (70 - 40 cm total length), amount of the organic solvent (methanol and acetonitrile) were investigated and optimized.

Item Type:Article
ID Code:9207
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chiral separation, CM-β-cyclodextrin, dimethoxy-amphetamines, DM-β-cyclodextrin, paramethoxy-amphetamines, S-β-cyclodextrin, trimethoxy-amphetamines
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Wiley-Liss
eISSN:1520-636X
Publisher Policy:© 2013 Wiley Periodicals
Deposited On:27 Sep 2013 10:24

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