Burrai, Lucia and Nieddu, Maria and Pirisi, Maria Antonietta and Carta, Antonio and Briguglio, Irene and Boatto, Gianpiero (2013) Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified: cyclodextrins. Chirality, Vol. 25 (10), p. 617-621. eISSN 1520-636X. Article.
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An easy-to-prepare chiral CE method for the enantiomeric separation of 13 new amphetamine-like designer drugs, using CDs as chiral selectors, was developed. Sulfated-β-CD was found to be the best chiral selector among the three used (sulfated-β-CD, caroboxymethyl-β-CD, dimethyl-β-CD). The separation of the analytes was achieved in a fused-silica gel capillary at 20 °C using an applied voltage of +25 kV. The optimized background electrolyte consisted of 63.5 mM H3PO4 and 46.9 mM NaOH in water. Several electrophoretic parameters such as CD type, CD concentration (1 - 40 mg/mL), buffer pH (2.6, 3.6, 5.0, 6.0), length of the capillary (70 - 40 cm total length), amount of the organic solvent (methanol and acetonitrile) were investigated and optimized.
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