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Ruolo del polimorfismo HindlIII nella regolazione della pressione arteriosa e nell'invecchiamento

Rossi, Renata (2009) Ruolo del polimorfismo HindlIII nella regolazione della pressione arteriosa e nell'invecchiamento. Doctoral Thesis.

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Human essential hypertension is a major risk factor in the development of cardiovascular diseases and a major contributor to morbidity and mortality in modern societies. Determining of blood pressure (BP) is multifactorial, involving an interplay of genetic and environmental contributions. Preliminary data from AKEA study show that centenarian men had diastolic blood pressure 5mm Hg lower than centenarian women (P0,05), and 18 mmHg lower than sexagenarians of the same sex (P0,0001). The most peculiar characteristic of the AKEA centenarians was a female/male ratio of 2 to 1, lower than the ratio reported by previous study (generally more than 5:1). Althought BP is a multifactorial trait, likely under the control of a variety of genes, these results in Sardinian centanarians suggest, as a working hypothesis, that sex-linked loci may play a role in the control of blood pressure at advanced age. Extensive data from rodent models indicate a significative association between the Y chromosome and BP. The HindIII centromeric alphoid polymorphism has been reported to be associated with BP in three independent human population, although the results are discordant. Our objective was to test this relationship in a population of elderly Sardinians. Isolation, genetic drift, low immigration rate and higher endogamy resulted in a peculiar genetic structure of Sardinians, who are markedly different from other Caucasian populations. Our data don’t support the hypothesis that the HindIII polymorphismis a marker of cardiovascular risk in this cohort. The location of Y chromosome genetic variants that affect blood pressure are not known but may be found by the use of linkage studies of the PARs and analysis of BP variation in men with Y chromosome deletions.

Item Type:Doctoral Thesis
ID Code:917
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Hypertension, Y chomosome, HindIII polymorphism, longevity
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
Cicli, scuole e corsi:Ciclo 21 > Corsi > Fisiopatologia medica
Deposited On:18 Aug 2009 10:03

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