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ß-endorphin and cortisol levels in plasma and CSF following acute experimental spinal traumas

De Riu, Pier Luigi and Petruzzi, Valentino and Caria, Marcello Alessandro and Mameli, O. and Casu, Anna Rita and Nuvoli, Susanna Maria Francesca and Spanu, Angela and Madeddu, Giuseppe (1997) ß-endorphin and cortisol levels in plasma and CSF following acute experimental spinal traumas. Physiology & behavior, Vol. 62 (1), p. 1-5. ISSN 0031-9384. Article.

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DOI: 10.1016/S0031-9384(97)00099-1

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ß-endorphin and cortisol were measured in cerebrospinal fluid (CSF) and plasma by radioimmunological method (RIA) in two groups of rabbits with spinal cord traumatic injuries at cervical and lumbar levels, respectively with and without concomitant spinal shock and arterial hypotension, and in a group of sham operated animals as controls. The two groups with spinal lesions displayed a significant ß-endorphin increase in CSF, whereas the cortisol level remained unchanged both in the spinal traumatized rabbits and in controls. Both the opioid and the cortisol concentration rose significantly in plasma in all three groups and in particular resulted significantly higher in the cervical traumatized group where spinal trauma was associated with spinal shock and hypotension. However, no significant difference was found when beta-endorphin concentrations in plasma were compared between the sham operated animals and the spinal lumbar traumatized animals without concomitant spinal shock. The results seem to suggest that the ß-endorphin increase in CSF is related to the nervous tissue lesion, while its increase in plasma, like that of cortisol, is due to surgery or other stress factors inherent in the experiment. This independent behaviour of ß-endorphin in plasma and in CSF suggests its different origin in these two compartments.

Item Type:Article
ID Code:9097
Uncontrolled Keywords:ß-endorphin cortisol, plasma, CSF, spinal trauma
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/09 Clinica chirurgica veterinaria
Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
Copyright Holders:© 1997 Elsevier Science
Deposited On:05 Jun 2013 12:53

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