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Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination

Galeotti, Francesca and Massari, Marco and D’Alessandro, Roberto and Beghi, Ettore and Chiò, Adriano and Logroscino, Giancarlo and Filippini, Graziella and Benedetti, Maria Donata and Pugliatti, Maura and Santuccio, Carmela and Raschetti, Roberto (2013) Risk of Guillain-Barré syndrome after 2010–2011 influenza vaccination. European Journal of Epidemiology, Vol. 28 (5), p. 433-444. eISSN 1573-7284. Article.

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DOI: 10.1007/s10654-013-9797-8

Abstract

Influenza vaccination has been implicated in Guillain Barré Syndrome (GBS) although the evidence for this link is controversial. A case–control study was conducted between October 2010 and May 2011 in seven Italian Regions to explore the relation between influenza vaccination and GBS. The study included 176 GBS incident cases aged ≥18 years from 86 neurological centers. Controls were selected among patients admitted for acute conditions to the Emergency Department of the same hospital as cases. Each control was matched to a case by sex, age, Region and admission date. Two different analyses were conducted: a matched case–control analysis and a self-controlled case series analysis (SCCS). Case–control analysis included 140 cases matched to 308 controls. The adjusted matched odds ratio (OR) for GBS occurrence within 6 weeks after influenza vaccination was 3.8 (95 % CI: 1.3, 10.5). A much stronger association with gastrointestinal infections (OR = 23.8; 95 % CI 7.3, 77.6) and influenza-like illness or upper respiratory tract infections (OR = 11.5; 95 % CI 5.6, 23.5) was highlighted. The SCCS analysis included all 176 GBS cases. Influenza vaccination was associated with GBS, with a relative risk of 2.1 (95 % CI 1.1, 3.9). According to these results the attributable risk in adults ranges from two to five GBS cases per 1,000,000 vaccinations.

Item Type:Article
ID Code:9060
Status:Published
Refereed:Yes
Uncontrolled Keywords:Influenza vaccination, Guillain-Barrè syndrome, case–control study, self controlled case series
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Springer
eISSN:1573-7284
Copyright Holders:© the Author(s) 2013
Publisher Policy:Depositato in conformità con la politica di copyright dell'Editore
Deposited On:20 May 2013 11:07

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