Campus, Guglielmo Giuseppe and Cocco, Fabio and Carta, Giovanna and Cagetti, Maria Grazia and Simark Mattson, Charlotte and Strohmenger, Laura and Lingström, Peter (2014) Effect of a daily dose of Lactobacillus brevis CD2 lozenges in high caries risk schoolchildren. Clinical Oral Investigations, Vol. 18 (2), p. 555-561. eISSN 1436-3771. Article.
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Objectives A double-blind, randomised, placebo-controlled clinical trial was performed to validate the hypothesis that the use of lozenges containing Lactobacillus brevis CD2 (Inersan®, CD Investments srl) may reduce plaque pH, salivary mutans streptococci (ms) and bleeding on probing, during a 6-week period, in a sample of high caries risk schoolchildren.
Methods A total of 191 children (aged 6–8 years), presenting two to three carious lesions and a salivary ms concentration of ≥105 CFU/ml, were enrolled and divided into two groups, an L. brevis CD2 lozenge group and a no L. brevis lozenge group, and examined at baseline (t0), after 3 weeks (t1), after 6 weeks of lozenge use (t2) and 2 weeks after the cessation of lozenge use (t3). Plaque pH was assessed using the microtouch technique following a sucrose challenge. The area under the curve (AUC5.7 and AUC6.2) was recorded. Salivary ms were counted, and bleeding on probing was assessed.
Results At t0, the plaque-pH and ms concentration values were similar in both groups. Mean areas (AUC5.7 and
AUC6.2) were significantly greater in the control group at t1, t2 and t3. L. brevis CD2 lozenges significantly reduced salivary
ms concentrations and bleeding. The subjects from the
test group showed a statistically significant decrease (p=0.01)in salivary ms concentration. At t2, a statistically significantly lower bleeding value was recorded in the test group compared
with the control group (p=0.02).
Conclusions Six weeks’ use of lozenges containing L. brevis CD2 had a beneficial effect on some important variables related to oral health, including a reduction in plaque acidogenicity, salivary ms and bleeding on probing.
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