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HIV type 1 origin and transmission dynamics among different risk groups in Sardinia: molecular epidemiology within the close boundaries of an Italian Island

Ciccozzi, Massimo and Madeddu, Giordano and Lo Presti, Alessandra and Cella, Eleonora and Giovanetti, Marta and Budroni, Carla and Babudieri, Sergio and Mura, Maria Stella Anna and Zehender, Gianguglielmo and Salemi, Marco (2013) HIV type 1 origin and transmission dynamics among different risk groups in Sardinia: molecular epidemiology within the close boundaries of an Italian Island. Aids Research and Human Retroviruses, Vol. 29 (2), p. 404-410. eISSN 1931-8405. Article.

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DOI: 10.1089/aid.2012.0209

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Abstract

In Italy, the HIV-1 epidemic is still mainly sustained by the subtype B genetic form, although other and novel subtypes and circulating recombinant forms (CRFs) have been reported. A total of 215 HIV-1 pol gene sequences were collected between 1992 and 2010. Multiple alignments spanning subtype-specific HIV-1 B pol sequences were analyzed by Bayesian phylogenetic methods. Subtype B represented 90.7% (n=195) of the sequences. Three main clusters were detected. The root of the tree dated to 1987. Most of the observed viral gene flow events occurred from heterosexual to intravenous drug users (IDUs). Phylogenetic and molecular clock analysis showed an early HIV-1 subtype B introduction in the mid-1980s and dissemination within local risk-specific clusters. This is the first study to describe in detail the HIV-1 molecular epidemiology in one of the largest islands in the European basin. The future potential of the Sardinian epidemic as a hub between Southern and Northern Europe has to been considered.

Item Type:Article
ID Code:9014
Status:Published
Refereed:Yes
Uncontrolled Keywords:HIV-1 subtype B, circulating recombinant forms (CRFs), Sardinia
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Mary Ann Liebert
eISSN:1931-8405
Deposited On:10 May 2013 12:59

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