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Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation

Marchesi, Irene and Nieddu, Valentina and Caracciolo, Valentina and Maioli, Margherita and Gaspa, Leonardo and Giordano, Antonio and Bagella, Luigi Marco (2013) Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation. Journal of Cellular Biochemistry, Vol. 114 (3), p. 728-734. eISSN 1097-4644. Article.

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DOI: 10.1002/jcb.24414

Abstract

Cyclin-dependent kinase 9 (Cdk9) is a serine-threonine kinase, involved in many cellular processes. The regulatory units of Cdk9 are the T family Cyclins (T1, T2) and Cyclin K. Cyclin T2 has two forms termed Cyclin T2a and Cyclin T2b that arise by an alternative splicing of the primary transcript. Upon induction of muscle differentiation, MyoD recruits Cdk9/Cyclin T2 on muscle-specific gene promoter sequences. This complex is able to phosphorylate the C-terminal domain of RNA polymerase II, enhancing MyoD function and promoting myogenic differentiation. This work focuses on the characterization of two murine Cyclin T2 isoforms and the evaluation of the role of Cdk9/Cyclin T2 complexes during the skeletal muscle differentiation. This study emonstrated a predominant expression of isoform b in all stages of differentiation. Moreover, both isoforms of Cyclin T2 are able to activate the myogenic program but Cyclin T2b has a predominant role, in particular during the latest stages.

Item Type:Article
ID Code:9005
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cyclin T2, Cdk9, Myod, skeletal muscle differentiation, RNA polymerase II phosphorylation
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Wiley-Liss
eISSN:1097-4644
Copyright Holders:© 2012 Wiley Periodicals, Inc.
Deposited On:08 May 2013 17:02

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