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Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

Gabbiani, Chiara and Scaletti, Federica and Massai, Lara and Michelucci, Elena and Cinellu, Maria Agostina and Messori, Luigi (2012) Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications. Chemical Communications, Vol. 48 (95), p. 11623-11625. eISSN 1364-548X. Article.

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DOI: 10.1039/C2CC36610J

Abstract

Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.

Item Type:Article
ID Code:9004
Status:Published
Refereed:Yes
Uncontrolled Keywords:ESI-MS measurements, Atox-1, copper trafficking system
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Royal Society of Chemistry
eISSN:1364-548X
Deposited On:08 May 2013 16:29

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