Gabbiani, Chiara and Scaletti, Federica and Massai, Lara and Michelucci, Elena and Cinellu, Maria Agostina and Messori, Luigi (2012) Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications. Chemical Communications, Vol. 48 (95), p. 11623-11625. eISSN 1364-548X. Article.
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Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.
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