Marchesi, Irene and Bagella, Luigi Marco (2013) Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation. In: Radzioch, Danuta (ed). Chromatin remodelling, [S.l.], InTech. p. 119-152. ISBN 978-953-51-1087-3. Book Section.
Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2]. These heritable changes are ascribed to chromatin, which constitutes the
ultrastructure of DNA and whose modifications affect the genetic material functionality.
Differences in chromatin structure have been associated to transcription regulation [3-5] and chromosome stability [6,7], affecting both gene’s information, expression and heritability.
Noteworthy, these epigenetic modifications are involved in both transcriptional activation and repression, indicating their widespread role as modulators of gene expression in numerous biological processes [8,9].
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