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Improvements in understanding nickel toxicity and carcinogenesis through NMR studies: the case of nickel binding to histone H4

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2006) Improvements in understanding nickel toxicity and carcinogenesis through NMR studies: the case of nickel binding to histone H4. In: SCI 2006: 22. Congresso nazionale della Società Chimica Italiana: atti del congresso, 10-15 settembre 2006, Firenze, Italia. [S.l.], Società Chimica Italiana. p. 405. Conference or Workshop Item.

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Abstract

Although nickel has been shown to be an essential trace element involved in the metabolism of bacteria, archaea, plants and higher organisms, the carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals and it is probably due to alteration in gene expression rather than by direct DNA damage.
We have previously reported that Ni(II) is a potent suppressor of histone H4 acetyaltion, in both yeast and mammalian cells.
Here we present our recent results on the coordination ability of Ni(II) to the N-terminal tail of HIstone H4 achieved by the use of NMR techiniques like 1d, 2D Tocsy and Noesy H NMR experiments. A structural model of the peptide-Ni(II) complex has been calculated, pointing out the important structural changes occurring to the peptide upon coordination.

Item Type:Conference or Workshop Item (Poster)
ID Code:8975
Status:Published
Uncontrolled Keywords:Nuclear Magnetic Resonance spectroscopy, metal complex, histone H4
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Società Chimica Italiana
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:06 May 2013 10:38

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