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NMR study of Nickel binding to N-tail of Histone H4

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2005) NMR study of Nickel binding to N-tail of Histone H4. In: 1. European conference on chemistry for life sciences: understanding the chemical mechanisms of life, October 4-8, 2005, Rimini, Italy. Conference or Workshop Item.

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Abstract

Nickel has been shown to be an essential trace element involved in the metabolism of several species of bacteria, archea, plant and may yet be found to play a role in the metabolism of higher organisms. However, the carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals. The molecular mechanisms of nickel-induced carcinogenesis include interactions of this metal with major chromatin components causing alterations in gene expression rather than by direct DNA damage. The nuclear proteins, and in particular the most abundant among them, the histones, are able to compete for metal ions with even higher affinity for metal binding sites in other less abundant nuclear proteins or smaller molecules. Phagocytosis of insoluble particles of NiS by either macrophages or epithelial cells causes buildup of very high levels of nickel inside the cells after its intracellular dissolution catalyzed by the acidic pH of endocytic vacuoles, thus providing a continuous source of Ni(II) ions.

Item Type:Conference or Workshop Item (Poster)
ID Code:8972
Status:Published
Uncontrolled Keywords:H4 Histone, cancer, metal complex, nmr, peptide
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Additional Information:Abstract pubblicato in: 1. European conference on chemistry for life sciences: understanding the chemical mechanisms of life. Book of Abstracts. [S.l. : Società chimica italiana], 2005.
Deposited On:22 May 2013 13:41

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