Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella and Kowalik-Jankowska, Teresa and Kozlowski, Henryk (2005) Nickel Binding to Cap43 protein. In: 1. European conference on chemistry for life sciences: understanding the chemical mechanisms of life, October 4-8, 2005, Rimini, Italy. Conference or Workshop Item.
Cap43 has been reported to be specifically induced by nickel compounds in a variety of cell lines. Although
the function of the Cap43 protein (MW 43,000) is not clear, it does appear to be induced in response to an increase in
intracellular concentration of Ca2+, caused by nickel ion exposure in cultured human cells, for this reason it is named Cap43: Calcium protein 43,000. Cap43 protein is expressed at low levels in normal tissues however, in a variety of cancers, it is overexpressed in cancer cells. The high level of expression in cancerous status combined with the elevated stability of Cap43 protein makes it an excellent cancer marker.
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