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Interaction of Cap43 protein fragment with Ni(II) and Cu(II) ions

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella and Kowalik-Jankowska, Teresa and Kozlowski, Henryk (2008) Interaction of Cap43 protein fragment with Ni(II) and Cu(II) ions. In: Eurobic9: 9. European biological inorganic chemistry conference, 2-6 Settembre 2008, Wroclaw, Poland. [S.l.], [s.n.]. p. 329. ISBN 978-83-60043-10-3. Conference or Workshop Item.

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One of the research topics in our group is protein Cap 43, which seems directly related to the cellular response after nickel exposure, as well as to a number of cancers. The studies we carried out for several years started from a small peptide model of Cap 43 and were successively expanded to include a two-(TRSRSHTSEG-TRSRSHTSEG) and a three-repeated (TRSRSHTSEG-TRSRSHTSEG-TRSRSHTSEG) monohistidinic decapeptide fragment in its C-terminus. Such 20- and 30-amino acid sequences were tested for Ni(II)- and Cu(II)- coordination at different pH values, by both potentiometry and spectroscopic techniques (NMR, EPR, UV-Vis, CD). The two metals showed a slightly different behaviour towards coordination, and the interaction of Cu(II) ions with the two peptides started at pH values lower than those for Ni(II). What appeared clear was that in both cases each 10-amino acid fragment TRSRSHTSEG was able to coordinate a single metal ion to form a square planar 4N {4N} chromophore. The coordination mode involved an imidazole nitrogen from the His residue, and the amidic nitrogens from His, Ser, and Arg. At high pH values, further deprotonations were observed for the Cu(II) species.

Item Type:Conference or Workshop Item (Poster)
ID Code:8963
Uncontrolled Keywords:Cap43 protein, nickel, Cu(II) ions, interaction
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Copyright Holders:© Copyright by Faculty of Chemistry, University of Wrocław, Wrocław 2008
Deposited On:03 May 2013 08:07

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