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LRRK2 and vesicle trafficking

Sanna, Giovanna and Del Giudice, Maria Grazia and Crosio, Claudia and Iaccarino, Ciro (2012) LRRK2 and vesicle trafficking. Biochemical Society transactions, Vol. 40 (5), p. 1117-1122. eISSN 1470-8752. Article.

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DOI: 10.1042/BST20120117

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Abstract

Mutations in LRRK2 (leucine-rich repeat kinase 2) (also known as PARK8 or dardarin) are responsible for the autosomal-dominant form of PD (Parkinson's disease). LRRK2 mutations were found in approximately 3-5% of familial and 1-3% of sporadic PD cases with the highest prevalence (up to 40%) in North Africans and Ashkenazi Jews. To date, mutations in LRRK2 are a major genetic risk factor for familial and sporadic PD. Despite the fact that 8 years have passed from the establishment of the first link between PD and dardarin in 2004, the pathophysiological role of LRRK2 in PD onset and progression is far from clearly defined. Also the generation of different LRRK2 transgenic or knockout animals has not provided new hints on the function of LRRK2 in the brain. The present paper reviews recent evidence regarding a potential role of LRRK2 in the regulation of membrane trafficking from vesicle generation to the movement along cytoskeleton and finally to vesicle fusion with cell membrane.

Item Type:Article
ID Code:8938
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cytoskeleton, endocytosis, exocytosis, leucine-rich repeat kinase 2 (LRRK2)
Subjects:Area 05 - Scienze biologiche > BIO/11 Biologia molecolare
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Portland Press
eISSN:1470-8752
Copyright Holders:© The Authors Journal compilation © 2012 Biochemical Society
Deposited On:29 Apr 2013 08:09

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