Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2009) Spectroscopic aspects of Copper(II) interaction with a Cap43 protein fragment. In: ISMEC 2009: 20. Italian-Spanish Congress on thermodynamics of metal complexes, 7-11 June 2009, Pisa, Italia. [S.l.], [s.n.]. p. 43. Conference or Workshop Item.
One of our research topics during the past years has
been an interesting protein, called Cap43, which
seems to be specifically induced by nickel ions.
This aspect triggered our attention because some other
proteins are expressed after metal exposure, but none
of them appeared to be induced by a single metal.
Different articles reported about the different
processes in which Cap43 protein is involved
(hypoxia, cellular growth and differentiation, stress
response, regulation of lipids distribution, cancerous
states and metastasis suppression just to quote some),
but so far no one has been able to cast a light on the
effective role of Cap43 inside the cell. Its specificity
to nickel, though, appeared to us a good starting point
for our investigation, and in our most recent
studies we have proposed a detoxification function for
this protein. In fact, we found that a characteristic
sequence at its C-terminus, where a mono-histidinic
10 aminoacid fragment is repeated consecutively
three times, is able to effectively bind up to three
metal ions at certain pH values.
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