Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2009) Bidimensional NMR reveals new feature of Nickel(II) binding to a fragment of Cap43 protein. In: ISMEC 2009: 20. Italian-Spanish Congress on thermodynamics of metal complexes, 7-11 June 2009, Pisa, Italia. [S.l.], [s.n.]. p. 86. Conference or Workshop Item.
Since its discovery, our research group chose Cap43 protein as an interesting subject for our studies because of its striking characteristic of being specifically induced by nickel(II) ions. Nickel is a well known pollutant and
carcinogenic agent, and the mechanisms involved in its toxicity are slowly being revealed. Although Cap43 seems to participate in a number of events occurring inside the cell (like cell growth and differentiation, stress response, and hormone response, but also in cancerous states and metastasis suppression) we still do not know what its real function might be. However, the fact that Cap43 is specifically induced by nickel ions gives us a hint about its possible role as a detoxifying agent. In fact, in analogy with other proteins expressed after exposure to different metals and with the task of binding the dangerous ions to eliminate them from the cellular environment (like metallothioneins, for instance), we might think also Cap43 could exert a similar function towards nickel.
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