Peana, Massimiliano Francesco and Zoroddu, Maria Antonietta and Medici, Serenella (2011) Manganese and Parkinson’s disease: new findings through a yeast protein study. In: ISMEC 2011: 22. International symposium on metal complexes, June 13-16, 2011, Giardini Naxos, Italy. [S.l.], ISMEC Group / Università degli Studi di Messina. p. 80. (ISMEC GROUP SERIES, 1). ISSN 2239-2459. Conference or Workshop Item.
Parkinson Disease (PD) is a neurodegenerative pathology whose causes have not been yet fully clarified. For this reason it is also called an idiopathic (with no known or identifiable causes) syndrome, although some PD types can have a genetic or a post-traumatic origin, and different risk factors like exposure to some pesticides. Recently it emerged that also exposure to manganese (i.e. in welders or miners) can cause a PD-like syndrome (Parkinsonism), and a connection between genetic and environmental causes of Parkinson's disease has been
discovered: a genetic interaction between two Parkinson's disease genes (alpha-synuclein and PARK9, alias ATP13A2) was found, and it was determined that the PARK9 protein can
protect cells from manganese poisoning.
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